1919.] The Sixth Indian Science Congress. eexv 
INTRAMUSCULAR QUININE. 
Twelve Past pa 0 of bihydrochloride on alte e days combined 
with 30 grains of quinine sulphate orally on the intervening days and 15 
grains of the dich me salt early on the days of injectio Other methods of 
oral administration were combined with intr atihisdicles injection. The 
results show that Sing ure i not prevented but that the peripheral 
blood was tele in 24 
TREATMENT OF INITIAL INFECTIONS. 
Initial infections are much more easily poms” ia tiger 
One of the most important facts demonstrated in recent times is thatif 
initial infections are treated with large doses (30 to 45 pn daily) for a 
sufficient period (not less than me Badge omplete ake waren of the 
disease may be hoped for in the majority of cases. It is wrong to reduce 
the dose after the circulation is leas ed of the parasites. One may 
develop in this way a quinine-resistant parasite. Putas much quinine 
into the system as practicable without injuring the patient, if not orally, 
then either intramuscularly or intravenously. 
In malignant tertian fiiteotindy s give quinine when a large number of 
parasites in association with concentrated pigment indicate that a 
sa 
a nin 
and for long periods unless it i is orderly t the patient has malaria and 
af 
One may d 
patient by pushing the drug unnecessarily The diagnosis of the 
i8 easy an potas should always be 9 e before quinine treatment is adopted. 
On t endeavour t me “the possibility of relapses by early, 
vigorous an mr well- wustaine d “treatin ent. The older the a-exual cycle of 
the parasite associated wit a relapse the more Sonatas it is to quinine. 
f quinine fails to control vaelaaiaas in the blood faulty absorption should 
lle suspected. It is possible, though not proved, that the parasite may 
me i q ype 
igures 8 cl 
instituted show ie out of 750 ¢ examined 193 were missed at the 
t examination. In this divighostr the old diagnosis of fever of uncer- 
tain De ge rapidly per place to malaria; the same applies to the VIth 
Divi 
DIET. 
Sufficient attention is not paid to diet and rest in the treatment of 
raalaria, ne, spe in the treatment of relapses. The system should be 
well nourished, toned up and adequately rested. acca | patients in 
bed for hibit fernuevale is useful. 
ConcLtUDING REMARKS. 
Quinine is still the best remedy we possess for malarial fevers. 
an untreated population. Quinine may fail to cure c ar a 
f cases, but properly admi: red, it controls t 
sease. know of no better remedy its value should not on any 
unt be decried. While quinine will cure malaria 
acco 
bed a search for other drugs for this purpose should not - made. Any 
w drug is not likely to replace quinine but supplement i 
