May 27, 1904.] 



SCIENCE. 



831 



tlie new compounds being about as poisonous 

 as quinine itself. The results of the experi- 

 ments with hydrochlorquinine are of special 

 interest; these showed that the addition of 

 H and CI decreases the toxicity for mammals 

 while increasing it for infusoria. Thus the 

 amount of hydrochlorquinine required to kill 

 mice was two and a half times as much as 

 that of quinine, while the former substance is 

 distinctly more poisonous to certain infusoria 

 than the latter. It is possible that hydrochlor- 

 quinine (or similar compounds) will be found 

 to be more effective than quinine, in the 

 treatment of malaria, and further work 

 along these lines may result in the discovery 

 of quinine derivatives which will be of value 

 in certain diseases, caused by protozoa, in 

 which quinine is of little value. Further ex- 

 periments are in progress. 



Beport on the Metabolism, of a Case of 

 Diahetes Mellitus : A. E. Handel and Gra- 

 ham LusK. 



The case was a young man whose urine con- 

 tained no albumin, little ammonia, only a 

 small amount of acetone and no /? -oxybutyric 

 acid. All these symptoms are said to justify 

 a favorable prognosis. The patient was put 

 on three different diets for three successive 

 periods : Diet I. — Rich cream, oatmeal, meat, 

 eggs, butter; Diet II. — Same as I., with 100 

 grams of levulose; Diet III. — ^Rich cream, 

 meat and eggs. The oatmeal was used on ac- 

 count of the favorable results obtained by 

 Von Noorden. 



Diet III. was practically a meat-fat diet. 

 Upon this diet the polyuria decreased and the 

 sugar fell from 8 to 4 per cent., both of which 

 phenomena would be favorably interpreted by 

 the clinician. But on calculating the ratio be- 

 tween sugar and nitrogen in the urine (after 

 deducting the sugar fed in the cream) the 

 relation between the two was found to be 3.65 

 grams of dextrose to 1 gram of nitrogen, as 

 follows : 



Dextrose, Nitrogen, 



3904. grams. grams. D:N. 



March 2 82.7 23.0 3.60: 1 



3 87.1 23.8 3.65: 1 



4 100.7 27.5 3.66: 1 



It will be noticed that the sugar and nitro- 

 gen rise and fall together. The amount of fat 



fed varied, but did not affect the ratio. The 

 sugar production is therefore parallel to the 

 proteid metabolism. Since 1 gram of urinary 

 nitrogen represents the destruction of 6.25 

 grams of proteid, we can calculate the sugar 

 production from proteid. This D:ISr ratio is 

 the same as that obtained in our laboratory in 

 phlorhizinized dogs. It has also been obtained 

 by others in the human subject, but has been 

 falsely interpreted as indicating the produc- 

 tion of sugar from fat. It represents the 

 maximum output of sugar from proteid and a 

 complete intolerance for carbohydrate. It is 

 probably the most grievous prognostic sign in 

 diabetes. 



A calculation shows that the carbohydrates 

 in the oatmeal and levulose were nearly quanti- 

 tatively eliminated in the urine when the 

 patient was under the influence of Diets I. 

 and H. 



The patient rapidly lost in weight and died 

 in coma five weeks after the completion of the 

 above investigation. 



Antihmmolytic Properties of the Serum of 

 Nephrectomized Babhits: S. J. Meltzer 

 and William Salant. 



In studying the properties of the blood of 

 nephrectomized rabbits it was found that bul- 

 lock's seriun, which is distinctly hemolytic, 

 for normal rabbit's blood, was less so for the 

 red cells of nephrectomized rabbits. It was 

 found, further, that the serum of nephrecto- 

 mized rabbits contains a distinct antihsemolytic 

 element which is destroyed by heating for an 

 hour at 58° 0. On Hhe other hand, the 

 ' washed ' red cells of nephrectomized rabbit's 

 blood are at least no more resistant to the 

 hsemolytic influence of bullock's serum than 

 the red cells of normal rabbit's blood. 

 On the Influence of Suprarenal Extract upon 

 Absorption and Elimination, with Demon- 

 stration: S. J. Meltzer and John Auer. 

 In a series of experiments it was found that 

 a previous intravenous injection of adrenalin 

 will make a rabbit resistant to a surely fatal 

 dose of strychnine. (Such an experiment was 

 demonstrated to the society.) In experiments 

 with subcutaneous injections of fluorescein it 

 was also found that in the animal which had 

 previously received injections of adrenalin the 



