Mabch 15, 1907] 



SCIENCE 



405 



The Relative Value of Calcium, Sodium, 

 Sodamide and Sodium Ethylaie in Pro- 

 moting the Claisen Reaction: J. Bishop 

 Tingle and Ernest B. Goesline. 

 The experiments were carried out with 

 camphor and various esters employing the 

 condensing agents mentioned above. The 

 effects of temperature, solvent and of cer- 

 tain other factors were studied. The best 

 agent is sodium wire ; calcium and sodamide 

 are about equal in condensing power, but 

 are decidedly inferior to sodium; sodium 

 ethylate is the least active condensing ma- 

 terial. The effect of the solvent is very 

 marked, it is independent of the tempera- 

 ture and the question is raised as to the 

 possibility of its playing a deiinite chemical 

 part in the condensation, similar, perhaps, 

 to its role in the formation of the Grignard 

 reagent. 



Preparation of Aniline Derivatives of 

 Succinic and Phthalic Acids: J. Bishop 

 Tingle and Marshall P. Cram. 

 The current methods for the preparation 

 of succinanil and of succinanilic acid have 

 been somewhat modified. Succinanilide 

 has been prepared by a new and simple 

 method. A modified process for the prep- 

 aration of phthalanil is described and also 

 some experiments regarding the prepara- 

 tion and relative stability of phthalanilic 

 acid and of phthalanilide. 



Hydrazones of Aromatic Hydroxyketones; 



Alkali-Insoluile Phenols: Henry A. 



ToREEY and H. B. Kipper. 



It was found that many aromatic 

 hydroxyketones, such as, pseonol, resodi- 

 acetophenone, dibenzohydroquinol and di- 

 benzoresorcinol gave stable phenylhydra- 

 zones. These hydrazones, though from 

 their method of preparation they would 

 appear to have one or more free hydroxyl 

 groups, are, nevertheless, insoluble in aque- 

 ous alkalies. It is possible that the insolu- 

 bility of these compounds may be due to 



their having a quinoid structure, and that 

 no hydroxyl group is actually present. 



Quinazolinecarloxylic Acids: M.T.Bogert, 

 J. D. WiGGiN and J. E. Sinclair. 

 The authors converted 3-amino-l,4- 

 xylene and 4-amino-l,3-xylene, into their 

 acetyl derivatives, oxidized the latter to the 

 corresponding phthalic acids, changed 

 these aminophthalic acids into their acetan- 

 thranils, and prepared quinazolinecar- 

 boxylie acids from the latter by condensa- 

 tion with various primary amines. 



Isomeric Oxygen and Nitrogen Ethers in 

 the Quinazoline Group: M. T. Bogert 

 and H. A. Sedl. 



The authors prepared various quinazo- 

 line ethers of the type -OR and -NR by 

 alkylation of the hydroxyquinazolines and 

 by other methods. They find that methyl 

 iodide invariably gives the -NR compound, 

 while ethyl iodide ■ generally yields the 

 oxygen ether. 



4-Aminophthalic Acid and Some of its 

 Derivatives: M. T. Bogert and R. R. 

 Renshaw. 



A description of the methods of prepara- 

 tion and properties of 4-aminophthalic 

 acid and the following derivatives: the 

 hydrochloride, a number of metallic salts, 

 the anhydride, imide, monomethylamino- 

 imide, the 4-monoamide of trimellitie acid, 

 the dimethyl succinimido- and dimethyl 

 phthalimidophthalate, and the 3,4-dimethyl 

 ester of diphthalylurea. 



Synthesis of 7-Nitroquinazolines from 4- 

 Nitroorthotoluidine : M. T. Bogert and 

 W. Klabee. 



4-nitroacetanthranil was condensed with 

 various primary amines, both aromatic and 

 aliphatic, thus producing the 7-nitro- 

 2-methyl-4-ketodihydroquinazoline deriva- 

 tives. The amines employed included 

 amino-esters, nitriles and diamines. 



