486 



SCIENCE 



[N. S. Vol. XXXII. No. 823 



Meclianical Stimulus to Crystallization: S. W. 

 Young. 



Zinc Ammonium Sulphate: Eloise Jameson. 



Conductivity of some Solutions in Ammonia- 

 water Mixtures: Wm. H. Sloan. 



DIVISION OF ORGANIC CHEMISTEY 



Stilbasoles in the Quinazoline Group: M. T. 



BoGEBT and G. D. Beal. 



2-methyl-4-quiQazoloiies and 3-ainino-4-quinaz- 

 olones both condense with aromatic aldehydes, 

 the condensation taking place with either the 

 methyl or the amino group, or both. The prod- 

 ucts obtained by the condensation with the methyl 

 group are of stilbazole type, those with the amino 

 group are somewhat analogous to the Schiff bases. 

 The aldehydes used were benzaldehyde, salicyl- 

 aldehyde, vanillin and cinnamie aldehyde. Very 

 strangely, no good condensations were obtained 

 with citral or with furfural. The aldehydes con- 

 dense first with the amino group and then with 

 the methyl group. When the products are treated 

 with strong hydrochloric acid the aldehyde group 

 is easily broken away from the nitrogen but not 

 from the carbon union. Various derivatives were 

 prepared and studied. 

 Isocampholactone : W. A. Notes and A. W. HoM- 



BERGEB. 



When isocampholactone is treated on the water- 

 bath with nitric acid (1.27) a nitroisocampho- 

 lactone, CoHijOjN, is formed. This gives an amine 

 and a hydroxylamino compound by reduction with 

 tin and hydrochloric acid or zinc and acetic acid, 

 respectively. The nitrolactone gives an amide, 

 C0H10N0O3, on treatment with ammonia and an 

 acid, C'cHjNO,, on treatment with sodium hy- 

 droxide. At the same time with the nitroisocam- 

 pholactone a small amount of a lactone acid, 

 CsHuOj. was also formed. From this an amide, 

 CjHisNOj, was prepared. 

 Separation of aa' -dimethyladipic Acid into its 



Optical Isomers and Synthesis of Laurolene: 



W. A. Notes and L. P. Ktbiakides. 



Although there seems to be no reason, theoret- 

 ically, why dialkylsuceinic acids and other acids 

 of a similar type should not be capable of separa- 

 tion into their optical isomers, all attempts to 

 effect such a separation have, heretofore, been 

 unsuccessful. Lean and some others have gone 

 so far as to suppose that there must be some 

 reason, inherent in the nature of these compounds, 

 why such a separation is impossible. By means 

 of the acid brucine salt we have obtained without 

 serious difficulty both the dextro and levo forms 



from the racemic aa'-dimethyladipic acid (m.p. 

 72° ) . Dimethyl-cyclopentanone prepared from the 

 active acid proved to be inactive. From the 

 ketone trimethyl-cyclopentanol was prepared by 

 the Barbier-Griguard reaction. This loses water 

 on distillation, or more completely on warming 

 with anhydrous oxalic acid, giving laurolene, thus 

 confirming Eykmann's formula for the latter and 

 also the results previously obtained by Noyes and 

 Derick from its oxidation. 

 Derivatives of Isoc-amphoric Acid: W. A. Notes 



and LuTHEB Knight. 



Aschan's method of preparing isocamphoric 

 acid has been improved by using a much larger 

 proportion of camphoric acid and decreasing the 

 amount of hydrochloric acid in the sealed tubes. 

 From isocamphoric acid the acid methyl esters 

 and from this /3-isocamphoramidic were prepared. 

 The last gave, by Hofmann's reaction, an amino 

 acid which is called, provisionally, dihydroamino- 

 iso-o-campholytie acid. This gives with nitrous 

 acid, not the dihydrohydroxyisocampholytic acid 

 which was expected, but Z-dihydrohydroxycampho- 

 lytic acid identical with the same acid prepared 

 by a different method some years ago. An unsat- 

 urated acid, probably the d-a-campholytic acid 

 which .was to be expected, and a lactone were also 

 formed. 

 Decomposition of Nitrosophthalimidine in the 



Presence of Alcohol: W. A. Notes and James 



A. Coss. 



Some years ago Noyes and Taveaur discovered 

 that when the nitroso derivative of the anhydride 

 of aminolauronic acid is decomposed in the pres- 

 ence of alcohol and sodium hydroxide a compound 



f C3H, / I ) 



is formed, if similar compound is obtained in 

 small amount from nitrosophthalimidine, but the 

 principal product is an oil which is free from 

 nitrogen. This oil gives phthalic acid by oxida- 

 tion and orthotoluic acid and ethyl iodide on 

 heating with hydriodie acid, but its nature has not 

 yet been fully established. 

 Conversion of Quinine into Quinotoxine: H. C. 



Biddle and T. B. Kelly. 



As a possible explanation of the occasional 

 toxicity of the cinchona alkaloids, it is found 

 that the formation of quinotoxine from quinine 

 (so cinchotoxine from cinohonine) is determined 

 largely by the action of certain organic acids as 

 catalytic agents. In the presence of mineral acids 



