Deoembeb 9, 1910] 



SCIENCE 



821 



verted into glycines by the action of 

 chloracetic acid: 



NH • CH, • COOH 



\ 



I /ONa 

 As=0 

 \0H 



All kinds of azo and polyazo derivatives 

 were obtained by diazotizing atoxyl and 

 combining with the usual coupling sub- 

 stances, and the amido group was converted 

 by diazotization into the oxy group or sub- 

 stituted by halogen. 



Urea and thio-urea compounds were 

 made from atoxyl, and substances of the 

 following composition were obtained: 



NH— CO- 



l/OH 

 As=0 

 \0H 



< 



NH— CS-N< 



I 



\/ 



I /OH 

 As=0 

 \0H 



Besides the paraamido compound, the 

 metaamido combination has been produced 

 and employed for the various syntheses. 



An arsinosalicylie acid has been ob- 

 tained by resorting to anthranilic acid in- 

 stead of anilin in the reaction 



OH 



I 

 /V 



i I 



-COOH 



T/OH 

 Ab=0 

 \0H 



and by the iise of alpha naphthylamin an 



alpha naphthol arsinic acid was produced 



OH 



I 

 /\ 



I I 



\/" 



/OH 

 As=0 

 \0H 



By various forms of reduction Ehrlich ob- 

 tained from atoxyl a product called p. 

 aminophenylarseneoxid 



NHj 



I 

 /\ 



I I 



I 



As= 



=0 



and diaminoarsenobenzol 



NH,- 



"\_ 



-NHj 



A derivative of the latter substance is 

 spirarsyl of the formula: 



NH- 



-/ \-As=A8-/ N-NH 



"\ /-^"-' \ / , 



CHj— COONa NaOOC— H^C 



By reduction with sodium amalgam 

 diaminodihydroarsenobenzol is obtained 



NH, 



./ 



-As(OH)— As(OH)-/ ^NHj 



From oxyphenylarsinic acid, which is 

 produced by heating phenol with arsenic 

 acid, phenolparaarseneoxid is obtained by 

 reduction, which upon treatment with 

 hydrosulfite furnishes paraarsenophenol 

 OH OH 



I I 

 I i 

 \/ 



I /ONa I 



A3=0 As=0 



\0H Phenolparaarseneoxid 



Oxyphenylarsinic acid 



I I 



0H-<^ 



\— As=As— / 



-OH 



p. Arsenopbenol 



' ' 606 ' ' is also a derivative of oxyphenyl- 

 arsinic acid, and is produced from it by 

 nitrating and reducing the thus obtained 

 nitrooxyphenylarsinic acid to the amido- 

 oxj'phenylarsinic acid. By treatment with 

 weak reducing agents this substance fur- 

 nishes the "606" preparation. As the 

 formula shows, the product contains two 

 atoms of trivalent arsenic, that is, the un- 



