July 16, 1915] 



SCIENCE 



103 



sugar a fair amount (10 per cent.) of another 

 crystalline substance melting at 98° and showing 

 levorotation (a)]J = — 41.6° in chloroform. 

 Analysis shows it to be a new pentacetate of galac- 

 tose. There are accordingly three isomeric forms 

 of the pentacetate. Full paper to appear soon in 

 the Journal of the American Chemical Society. 



Friend E. Clark and Samuel F. Cox: Some De- 

 rivatives of Chlor-methyl Ether. 



NoBMAN A. Dubois: Eop-seed Oil. 



Carl O. Johns : Researches on Purines : On a New 

 Synthesis of Purines. On 2-Oxy-S-Thiopurine, 2- 

 Oxy-8-Methyl Merca-ptopurines, 2-Oxy-8-Methyl 

 Aminopurine and 2-Oxy-6-, 9-Dimethyl-8-TMo- 



Mercaptopurines when treated with methylamine 

 yield methyl-aminopurines and methyl mercaptan. 

 The change of 2-osy-8-methyl mercaptopurine into 

 2-oxy-S-methylaminopurine is offered in substan- 

 tiation of this statement and the preparation of 

 these products is described. 



Carl 0. Johns: Researches on Thioamino Acids. 



On Thiohippuric Acid and Phthalyl-aminothio- 



acetio Acid. 



Thiohippuric aeid (m. p. 104°) was prepared 

 from hippuryl chloride and potassium hydrogen 

 sulfide. Upon hydrolysis with warm water hydro- 

 gen sulfide and hippuric acid resulted. With 

 iodine in alkaline solution it gives dithiohippurio 

 acid — a reaction characteristic of the thio acids. 

 The anilide of hippuric acid is described. 



Similarly, phthalyl-a-aminothioacetic acid was 

 prepared from phthalylglycyl chloride and po- 

 tassium hydrogen sulfide. It crystallizes from 

 benzene in plates which melt at 112°. The anilide 

 of phthalyl-a-aminoacetic acid is described. 



B. G. Feinberg: Citral, and its Determination. 



C. G. Derick: The Preparation of Trimethylene 

 Oxide. 



Since the commercial product ' ' Blizzard ' ' offers 

 a cheap source for trimethylene glycol, trimethyl- 

 ene bromide was prepared in large quantities very 

 cheaply from the action of 48 per cent. HBr with 

 subsequent saturation with gaseous HBr; yields 

 better than 90 per cent, being obtained. Tri- 

 methylene bromide heated to its boiling point with 

 PbO gave monomolecular trimethylene oxide 'boil- 

 ing at 52.3° under 745 mm. pressure. From the 



reaction flask a polymeric form of the oxide was 

 isolated which boils at 183° under 55 mm. pres- 

 sure. 



Silver oxide acts with almost explosive violence 

 upon the bromide if 100 grams of the latter is em- 

 ployed and only traces of the oxide are obtained. 



Mercuric oxide appears to act best of all, giving 

 mainly the monomolecular form. 



C. G. Derick and E. H. Vollweiler: The Use of 



Trimethylene Oxide in the Grignard Reaction. 



The Synthesis of Normal Primary Bexyl Alcohol. 



The polymeric form of trimethylene oxide was 



treated with magnesium propyl bromide in ether 



solution. The reaction is fairly rapid, generating 



heat. Upon distillation with steam the 7i-primary 



hexyl alcohol distils and is extracted with ether 



from the aqueous layer saturated with potassium 



carbonate. 



C. G. Derick and R. W. Hess: The Synthesis of 



■y-Acetylvalerianio Acid. 



Trimethylene bromide dissolved in absolute 

 methyl alcohol is treated with one molecule of po- 

 tassium cyanide. The 7-bromobutyronitrile formed 

 is purified by fractional distillation under dimin- 

 ished pressure. Yield of pure product 25 per cent. 

 It then condensed with acetoaoetic ester and the 

 resulting 7-eyanopropylacetoaeetie ethyl ester is 

 purified by distillation under 1 mm. pressure. 

 Upon hydrolysis with 20 per cent. HCl it gives the 

 desired acid. 



C. G. Derick and St. Elmo Bradt: The loniga- 

 tion Constants of Certain Ketoparaffine Mono- 

 basic Acids. 



After careful preparation and purification the 

 following acids have been measured by the con- 

 ductivity with the following results: pyroracemic 

 acid, fcf° = 3.643 X 10-= (below 0.005ON) ; levu- 

 linic acid, 10^° =■ 2.436 X 10"^ and 7-acetylvaleri- 

 anic acid, fef° = 2.295 X 10"'. 



The criterion "calculated A„" shows these re- 

 sults to be accurate to one tenth of one per cent. 



M. A. Eosanoff and M. M. Harrison: On the 

 Decomposition of Tertiary Amyl Esters. 



G. B. Feankforter and Lillian Cohen: Equili- 

 bria in the Systems of Methyl Alcohol, Ketones, 

 Water and Inorganic Salts, Part I. 



G. B. Frankporteb and Sterling Temple : Equili- 

 bria in the Systems of Propyl Alcohols, Water 

 and Salts. 



