300 Hallier, 
Nachdem ich Herrn Dr. Harris meine Bereitwilligkeit zu 
erkennen gegeben hatte, eine Untersuchung des fraglichen Orga- 
nismus vorzunehmen, sandte derselbe mir Galle von einem pest- 
kranken Rinde und schrieb dabei einen sehr ausführlichen Brief, 
welcher Folgendes von allgemeinem Interesse enthielt: 
I must not omit to mention to you how importantly, — per- 
haps causitively, — this spore — growth seems to be assosiated 
with the contagium and with the pathological results of this 
bovine pestilence. The blood is filled with the Cryptococci, ever 
for days before death as we have found by bleeding an infected 
bullock before death. And in the bile and biliary ducts the largest 
and most abundant crops of it are produced: some specimens 
give us examples that are quite similar to the Cryptococcus guttu- 
latus; and, by keeping the bill for 24 or 48 hours in a warm 
temperature, — say 78° Fahr. — we find the quantity in a single 
minimum of the fresh bile then multiplied manyfold. 
The unexampled engagement of the liver in this disease and the 
excessive production of bile when, by acute fatty change, the 
hepatic cells are half filled by fat and lastly, a beautiful demon- 
stration of reticular construction of the biliary radicles, — all 
go to show how important may possibly be the irritant or poi- 
sonous effect of the Cryptococcus and Micrococcus in bile and 
blood. 
The cattle die of acute and overwhelming Cholaemia and its 
results. The disease incubates during varying periods from 2 to 
3 weeks before the explosion or obvious symptoms of it are seen. 
Then death usually supervenes in about 48 hours. I have re- 
quested our excellent microscopist and histologist Dr. R. Cresson 
Stiles of this Board of Health to communicate to you in exact 
terms the discoverics he has made in this field, especially the 
results OL MIS ehortsat „Pilzeultur." ys cs) .: 
Der betreffende Brief war datirt vom 30. October 1868. 
Herr Dr. Harris übersandte mir zweimal Galle von pest- 
kranken Rindern in luftdicht verschlossenen Gläsern. In beiden 
Fällen war der botanische Thatbestand genau derselbe. 
Es liessen sich zweierlei verschiedene Elemente unterscheiden, 
nämlich erstens Micrococcus (a Fig. 8 Taf. VI). Dieser war in 
bei Weitem überwiegender Menge vorhanden, wie er denn im 
Blut ausschliesslich vorzukommen scheint. Wie die Figur zeigt, 
