652 SUMMARY OF CURRENT RESEARCHES RELATING TO 



more deeply stained by methylen-blue ; the second, an internal substance 

 or entoplasm, more centrally disposed, is less refractive and less deeply 

 stained. 



In the endoplasm of tbe pigmented amoeboid forms is distinguisbable 

 both in the unstained and stained conditions a nucleus, within which are 

 1-3 more deeply stained nucleoli. Without the nucleus is a vacuole. 



The authors have, further, observed that in one and the same mala- 

 rious patient the process of reproduction is effected in three different 

 ways: — (1) The division of the protoplasmic substance is complete, 

 many different corpuscles being formed, while of the mother plasmodium 

 only the pigment-corpuscles remain. (2) The division of the proto- 

 plasm is incomplete, one part of it remaining together with the pigment- 

 granules as an irregular granular mass. (3) The pigment becomes 

 arranged in small circles surrounded by protoplasm. From this 

 originate small pigmented bodies, some of which are in connection with 

 the parent, while others present a pigmented flagelliform prolongation. 



The transition from the crescent shape to the oval, from this to the 

 round, with the pigment heaped up in the centre, and finally to the 

 flagelliform condition, can be observed on the hot stage of the Microscope. 



Assuming that all these forms belong to one and the same species, 

 the Plasmodium malarise would have two chief phases of endocellular 

 development in the blood, viz. those peculiar to the amoeboid and those 

 peculiar to the crescent-shaped varieties, under the latter term being 

 included the spindle, oval, flagellate, and round forms. 



The authors consider, from its morphological characters, that the 

 Plasmodium malarise should be classed with the Sporozoa, and, to express 

 their position more accurately, placed under the class Gregarinidee, Order 

 Coccidiidse. 



