84 DR. A. E. BROWN ON THE (Jan. 12, 
In tuberculous subjects the usual result is a general rise of 
temperature within the first twelve-hour period, though in a few 
cases the rise has not appeared until the next day, or in many 
cases a complete destruction of the daily curve ensues, with or 
without a general rise. This last condition clearly represents the 
balance reached in the struggle between two opposing tendencies, 
the upward one due to tuberculin reaction and the downward one 
which is the normal nightly course, and in meaning is equivalent 
to a definite rise. Chart B (text-fig. 2) is of this character. In 
this case, a young rhesus monkey, the temperature before injec- 
tion ranged from 102°6° to 104-4°. 
Text-fig. 2. 
Chart B. 
FFIME [TAM |TAM|SP.M.7 PM [I PMSAM|ZAM[TAM|SP.M|7PMINPM|SAM|7AMIITAM|S PA, 
Macacus rhesus § juv. 
Temperature chart showing tuberculous reaction destroying daily curve, 
with no general rise. 
It may be noted that in every case showing reaction of either 
type, autopsy has shown tuberculous lesions *. 
The charts most difficult of interpretation, however, in the 
study of which quite a number of healthy monkeys were sacrificed, 
are those not infrequent ones in which there is no definite rise in 
temperature, and no complete destruction of the night drop, but 
only more or less of a failure to properly complete it. These cases 
are now held over for retesting after an interval of six or eight 
weeks, and occasionally the second test gives a positive reaction. 
It has not infrequently happened that monkeys have been retested 
as many as three times before a final conclusion was reached. 
Such charts call for nice discrimination, and, even with the most 
expert, in them must always le a possibility of error. 
In a few very advanced stages of general tuberculosis there was 
no reaction rise, and the daily curve was completed, so that a 
serious certainty of error would arise were it not for the fact that 
* J am not prepared at this time to suggest an explanation of the difference 
between our results and those announced by the Royal Commission on Tuberculosis 
(Second Interim Report, p. 44, London, 1907). If anything has been certain in our 
experience, it is that in not a single case of definite reaction has autopsy failed to 
show tuberculosis. 
