86 DR. A. E. BROWN ON THE [Jan. 12 
charts cannot be too strongly stated. It has been followed 
relentlessly throughout our work, and every doubtful case was in 
the end decided against the monkey. In every case when an 
animal was condemned, it was etherized and brought to the post- 
mortem table. 
A thoroughly complete system of prevention would perhaps 
require the retesting of each monkey in the exhibition series at 
least once a year, but this is no small under taking in an extensive 
collection, and we have restricted the practice to those concerning 
which suspicion arises based on ill-health or other indications. 
These are immediately removed to the Laboratory and reinjected. 
If the reaction is bad, the monkeys occupying the same cage are 
at once taken to the Laboratory and put through the same course. 
The infected cage as well as the adjoining ones are then thoroughly 
disinfected, 
Quite recently I have made a study of the history of every 
monkey and lemur that has been tested since March 1905, in the 
light of the records now in the Laboratory, consisting of two 
hundred and sixty-seven post-injection temperature charts, and 
complete post- -mortem records of nearly one hundred cases. 
Up to November 1908, the test has been applied to one hundred 
and sixty-three newly arrived monkeys belonging to Presbytis, 
Cercopithecus, Cercocebus, Macacus, Cynopithecus, Papio, Ateles, 
Cebus, Chrysothrix, Callithrix, and including a few of the genus 
Lemur. Of these, one hundred and four passed the test and were 
sent to the Monkey House. Of those not passed, twenty-five 
were promptly condemned on their reactions and showed tuber- 
culosis on autopsy. The remainder either died from other causes 
while in quarantine, or were etherized to learn the meaning of 
dubious charts, during the early and experimental stages of the 
work, 
Of the one hundred and four originally passed, ten have 
developed tuberculosis during the three and a half years that have 
elapsed, Three of these died in the exhibition cages, giving no 
sign of ill-health. The others were detected and returned to the 
Laborator y, Where they were either etherized or secluded. Seven 
of these cases are traceable with reasonable certainty to two 
infections from monkeys which were passed early in the tests on 
twenty-four hour records, whose charts would be considered 
doubtful in the ight of later experience. The three remaining 
ones were also passed early in the tests, two of them on vather 
uncertain charts, that of the third beimg of good quality though 
somewhat irregular according to our pr esent standards. This 
monkey, a male Cercopithecus ruber, tested in November 1906, 
died six weeks later from nephritis and fatty degeneration of the 
liver, and showed early miliary tuberculosis of the intestinal sub- 
mucosa. With this exception, no monkey passed since February 
1906 has as yet shown signs of tuberculosis, and more thana year 
has elapsed since the last one exhibiting it was removed from the 
Monkey House on October 16th, 1907. 
