LOCOWEED DISEASE OF SHEEP 381 



animal. The pupils were only moderately dilated. The animal was greatly emaciated 

 and undersized, and stood with head and ears drooping, hardly making a movement. 

 Observed to remain in one position for one hour and thirty minutes and then moved 

 only upon being disturbed. Every two or three minutes a brief spasm contracted the 

 abdominal muscles, less often the muscles of one of the legs. 



The vision of the animal was apparently good. She observed movements 10 or 20 

 feet away. When the hand was waved around slowly at a distance of 2 feet from 

 the animal, she became greatly alarmed and trembled, and shrank against the wall. 

 Hearing apparently acute. If hands were clapped together, even gently, up to a dis- 

 tance of 20 feet from the animal it quivered at the clap but paid no further attention. 

 Tactile sensation apparently not exaggerated. The end of the nose and skin of the 

 body were not unduly sensitive. 



September 26 at 12.30 p.m. animal chloroformed. Autopsy No. 1 performed at 

 once. Upon opening the spinal cord and brain, firm adhesions were found between 

 the dura and the base of the skull along the right side extending from the level of the 

 sella turcica posteriorly nearly to the foramen magnum. Upon removing the dura 

 an abscess was opened into between the dura and the base of the skull containing be- 

 tween 2 and 4 drams of thick, viscid, yellow pus with a faint, unpleasant, rather fishy- 

 odor. 



The brain was symmetrical, convolutions slightly flattened. The vessels not in- 

 jected except adjacent to abscess where the surface of the brain was roughened and a 

 small amount of exudate had collected in the pia-arachnoid. 



Longitudinal section of the head through the nares and roof of mouth presented 

 no abnormality and did not reveal the starting point of the abscess. Incisor teeth 

 were quite loose, and irregular in size, shape, and position. 



Subcutaneous and peritoneal fat almost absent. Muscles of the back and abdo- 

 men pale, reddish, and translucent. 



Pleural cavities dry; left lung adherent at the apex and at two or three points to 

 the diaphragm, being bound by quite firm, fibrous adhesions. Lung was small; 

 generally crepitant, and of a reddish pink color. The bronchi and vessels were clear. 

 The bronchi and trachea pale and dry. Scattered through the lung were 8 to 12 

 nodules varying from 2 mm. to 5 cm. in diameter, averaging 1.5 to 2 cm., fluctuat- 

 ing, raised, firmer, slightly tense with a yellow center surrounded by a narrow rim 

 of dark red consolidated lung. These areas were the parts adherent t'o the diaphragm 

 and apex. On section of such a nodule, in the center was found a core of .semi- 

 solid, semi-purulent, cheesy, material about two-thirds the size of the nodule, con- 

 tained in a smooth-walled, cyst-like cavity surrounded by the red, consolidated rim 

 of lung. No miliary nor conglomerate tubercles were found in the consolidated 

 regions. The lymph glands at the hilum of the lung were not large nor caseous. 



The right lung presented the same appearance as left, and contained from 8 to 

 10 nodules. 



Heart. Parietal and visceral pericardial layers were normal. A few cubic centi- 

 meters (3 to 5) of clear, amber, fluid were present. The subepicardial fat almost 

 absent. The heart valves were clear and delicate. The cavities appeared normal, 

 the muscle was semi-translucent, reddish brown; the heart weighed 35 grams. 



Spleen weighed 100 grams, measured 12 x 8 x 2 cm., surface smooth, consistence 

 soft, color dark red; on section uniform in appearance, not opaque and apparently 

 was normal. 



