LOCOWEED DISEASE OF SHEEP 383 



contained numerous large desquamated endothelial cells with rather abundant 

 pink cytoplasm. Among them were a number of cells showing the nuclear changes of 

 cell division. Many of these desquamated cells contained what appeared to be hemo- 

 globin. In the cell columns also were found evidences of cell division. The peripheral 

 sinus was not dilated. Diagnosis — Lymphoid hyperplasia. 



Diaphragm. Section was characterized by the presence of about a dozen cysts 

 like those found in the myocardium, the cyst being enclosed within a muscle cell, 

 although there was no reaction nor cell accumulation around the cyst. A cross sec- 

 tion of peripheral nerve presented no abnormality. 



Anatomical diagnosis. E.xtradural basilar abscess; multiple bronchioctatic 

 abscesses in lungs; bronchopneumonia; Cyslicercus tenuicollis adherent to broad 

 ligaments Thymnosoma aclinioides infection, biliary hepatitis; emaciation, irregular 

 incisor teeth. Sarcocystis lenella. 



C-iSE No. 2. Male, yearling sheep on Briggs-Ellis Ranch; Mr. Vestal's house; 

 Big Timber, Montana. September 28, 1003. 



This animal was picked out from the same bunch of invalids as No. 1, it being 

 considered about the worst locoed member of the band e.xcept No. 1. The sheep 

 had been at Vestal's Ranch for nearly two weeks, having been brought from a dis- 

 tant ranch on account of their sickness. Like the other sheep in the bunch, this one 

 was undersized, thin, emaciated, walked with a weak gait, the hind legs held rather 

 far apart and the legs being used in a slightly clumsy manner, somewhat suggesting 

 the idea that the animal was walking on stilts. Not all the animals had equal dif- 

 ficulty in walking, some going with perfect ease. Some of the weaker animals looked 

 dull and apathetic. None seemed to be nervous, or excitable, except No. 1. The 

 animals did not show any tremor. They fed naturally, and fairly constantly. Rough 

 tests indicated that hearing and sight were normal and no abnormalities of sensa- 

 tion or of reflexes could be detected on superficial examination. 



It must be noted that the appearance of No. 1 was markedly different from that 

 of the other members of this flock and that the others showed differences among 

 themselves. The only symptoms which seemed fairly constant were (1) thinness or 

 even emaciation, and (2) weakness shown in the slow, uncertain gait and the awkward 

 posture when standing. 



No. 2 being typical of a dozen others in the bunch, was chloroformed, and at the 

 same time the jugular vein and carotid artery were cut. Postmortem examination 

 was made at once at 3 p.m., September 28. 



Autopsy No. 2. The yearling measured from tip to tip about one yard. Weight 

 less than 15 pounds. Emaciation extreme. Skin, eyes, nose, head and ears presented 

 no abnormality. Incisor teeth were loose, and irregular in size and location. The 

 molar teeth were very black. The interstices between the teeth were filled with 

 tough, blackened fiber. Subcutaneous and peritoneal fat very scanty. Peritoneal 

 surface smooth and glistening. In peritoneal cavity were found from 50 to 100 cc. of 

 clear fluid, and eight soft, clear, watery parasitic cysts between 2 and 6 cm. in diameter 

 were between the folds of the omentum. The cysts had no relation to vessels or other 

 structures and were filled with a soft, gelatinous, material containing one short, 

 ringed, cylindrical, worm-like structure, 0.25 to 0.5 cm. in length, 0.25 cm. in diameter, 

 from which fine threads reached out into the jelly. At the rounded end of this worm- 

 like structure was a linear depression. Two or three smaller cysts were found else- 

 where, two being between the liver and diaphragm, and one forming the center of an 

 adhesion between the gall bladder and the small intestine. 



