LOCOWEED DISEASE OF SHEEP 387 



more diffuse. One or two large cells were met with at the very edge of the area of 

 coagulation necrosis which had an abundance of pink c3'toplasm and contained a con- 

 siderable number of nuclear fragments. T'hey did not, however, suggest the giant 

 cell of tuberculosis. The fibroblastic tissue did not seem to be especially rich in 

 capillaries. Among the cells were a good many with eccentric nuclei and rather pink- 

 ish purple cytoplasm, apparently of the plasma cell type but unusually large for 

 plasma cells. Adrenal, apparently normal; diaphragm showed no cysts. Bone marrow 

 showed an excess of giant cells, and of cells of the myelocyte type. Lymph gland 

 showed hyperplasia of the cell nests with crowding of lymph cells in the outer zone 

 of gland. The sinuses in the central part of gland were widely dilated, and contained 

 largo vacuolated endothelial cells having a cloudy, degenerating appearance. 



Anatomical diagnosis. Emaciation; irregular incisor teeth; Cysticercus tenuicol- 

 Us in peritoneal cavity; catarrhal inflammation of nares; patches of recent broncho- 

 pneumonia. Inflammatory nodules in kidney. Sarcocystis tenella in heart. Peri- 

 biliarj' cirrhosis; degeneration of outer zone of liver lobule. Lymphoid hyperplasia. 



C.iSE Xo. 4. 'At Mr. Clifford Kelly's ranch, Hunter's Hot Springs, Montana. 

 ' The sheep herder brought in a very sick yearling from the range, remarking, 

 "if this is not a locoed animal, I have never seen a case of loco." The animal was 

 thin, weak, stiff-gaited, dull, apathetic, with a rather rough fleece. 



Autopsy \o. 4. October 14, 1903. Animal bled to death and autopsied at once. 

 Female sheep, greatlj^ emaciated. Feet were apparent!}' normal. There was an ex- 

 tensive area of extravasation and edema over the buttocks. Subcutaneous fat very 

 greatly reduced. JMuscle pale, translucent, apparently normal. Peritoneal surfaces 

 in general smooth and glistening except for adhesions. No excess of fluid. Peritoneal 

 fat greath' reduced. Xo cysts free in peritoneal cavity. Pleural cavities contained 

 no excess of fluid. No adhesions. Right and left lungs were moderately voluminous, 

 pale, pink, crepitant; vessels clear. On opening into the smaller bronchi a number of 

 fine worms were found together with a considerable amount of thick, viscid, mucus. 

 The worms w-ere approximately an inch long, and as thick as medium or coar.se, cotton 

 thread, were motile, white with a dark line running spirally from head to tail. Six 

 were removed from one bronchus. On the surface of lung were one or two raised, dark 

 red, firmer areas not very sharply marked off and consolidated. On section a nodule 

 of consolidation was found to communicate with the bronchus containing worms. 

 Pericardial cavity contained small amount of clear, yellow fluid. Pericardial surfaces 

 smooth and shining. Fat very slight in amount. Heart valves clear, delicate. For- 

 amen ovale closed. Myocardium, pale, brown, translucent. Spleen small, surface 

 smooth, consistence soft. On .section, dark reddish brown. Malpighian bodies and 

 trabeculae clearly seen. Liver. Between diaphragm and liver, over the whole of the 

 anterior (ventral) surface were firm adhesions in which were cavities containing 50 

 to 100 cc. of slightly turbid, yellowish, bile-stained fluid together with two or three 

 fairly large, firm, elastic clots 10 or 15 x 1 or 2 cm. in size. This mass of adhesions, 

 etc., was in relation with an ulcerating surface on the liver which showed best on 

 section through the liver. On section, there was found in the middle of the main lobe 

 an ulcer 3 or 4 cm. in diameter, firm, slightly projecting, pale gray, fleshy looking, 

 with irregular margins extending deeply into the lobe. In the center of this area was 

 a necrotic rough-walled cavity, bile stained, about 2x3 cm. Elsewhere the liver was 

 brown, moderately soft, and showed little alteration. Gall bladder apparently 

 normal. Bile ducts emptj'. Stomach contained a normal amount of food. The lining 



