LOCOWEED DISEASE OF SHEEP 391 



of forming a capsule around the embryo. The mononuclear and polymorphonuclear 

 infiltration was extremely slight compared with the size of the embryo. 



Liver. The structure was not obvious, all of the cells being greatly swollen with 

 corresponding reduction of capillaries, most of which were nearly or quite obscured. 

 The liver cells were swollen, granular, and vacuolated. A second section showed that 

 there was a slight dilatation of the ducts, the duct epithelial cells being large with 

 pale, vesicular, bluish nuclei. Occasionally it appeared that there was a slight degree 

 of edema around the ducts, especially the larger ones, but there was no noticeable 

 fibrosis. In only one or two instances, after searching through two sections, could 

 regions be found in which there was an accumulation of cells around the duct. These 

 cells were chiefly mononuclears of a rather large size with moderately abundant cyto- 

 plasm. Spleen apparently normal. Cytolysis of red cells observed. Kidney showed 

 granular epithelium, otherwise normal. Section of lymph gland showed the cortex 

 with very little differentiation between germ centers and cell columns. The deeper part 

 of the gland showed very great dilatation of the sinuses with reduction in the amount 

 of lymphoid tissue between the sinuses, the result being that this part of the gland 

 looked almost like spongy tissue. It could be seen with particular clearness in this 

 section that the sinuses were lined with large, cloudy, pink cells, frequently cuboidal, 

 containing a large, moderately deeply stained but rather vesicular nucleus. These 

 cells were frequently present free in the sinuses, sometimes singly, sometimes in 

 clumps. The sinuses also contained free lymphoid cells. The large cells occasionally 

 contained a large amount of coppery yellow pigment, especially when the cells were 

 free in the lumen. The appearance of the lymph sinuses, owing to this peculiar ar- 

 rangement of the lining endothelium, suggested at first sight adeno-carcinoma. The 

 blood vessels in the glands were empty or showed only normal contents. 



Anatomical diagnosis. Thysanosoma actinioides infection of liver and pancreatic 

 ducts; emaciation; loose and irregular incisor teeth; Cysticercus tenuicollis with case- 

 ating cysts in capsule of liver and heart; larva (Oestrus ovis) in right supraorbital 

 sinus. Hyperplasia and phagocytosis in lymph gland. Sarcocystis tenella. 



Case No. 9. This was a badly locoed sheep from Mr. Cliff Kelly's invalid band 

 which had been fed on locoweed especially for purposes of experiment but presented 

 no alterations as the result of such feeding, and evidently did not like the weed as a 

 diet. The animal was dull, emaciated, stiff-legged and weak and had a slight coryza. 

 October 15, 1903, was bled from the carotid and examined at once. 



Autopsy No. 9. Fleece rough and ragged looking, front teeth loose and irregular. 

 Superficial examination negative. Fat almost absent. About 100 cc. of clear yellow 

 fluid in peritoneal cavity. Peritoneal surfaces smooth and glistening. Several 

 gelatinous cysts with motile embryos were seen in the peritoneal cavity. The common 

 bile duct, the cystic and hepatic ducts were tightly packed with tape-worms. The 

 diaphragm appeared clear, muscles red, uniform, translucent. Pericardial fluid 10 

 to 15 cc, cleai yellow. Pericardial surfaces smooth and glistening, the fat greatly 

 reduced. Myocardium reddish brown, translucent, valves clear and delicate. For- 

 amen ovale closed. Pleural surfaces dry and pale, free from adhesions. Lungs alike, 

 not very luminous, pink, crepitant, and free from nodules. Vessels at the root of the 

 lung were clear. Trachea and bronchi pale, containing a slight amount of sticky 

 mucus. In the finer bronchioles were one or two small thread like structures appar- 

 entl)' young worms around which there was very little reaction. Spleen smooth, soft, 

 small. On section, malpighian bodies and trabeculae clearly made out. Liver smooth, 



