: 198 SEMI-CENTENNIAL OF TORREY BOTANICAL CLUB 
the inhibiting power of the nerve was regained. When the 
Panaeolus infusion was painted directly on the heart the contrac- 
tions were in no way affected but the inhibiting function of both 
vagi was abolished. If the electrodes were then applied to the 
sinus there were the usual accelerated contractions followed by 
inhibition. Repeated application of the Panaeolus infusion to the 
heart of the turtle followed by stimulation of the sinus gave 
stronger contractions than the normal followed by inhibition. 
The effects of infusions Nos. 9, 10, and 12 were studied on turtles. 
With each infusion similar experiments were performed. It was 
found, however, that infusion No. 9 abolished the inhibiting action 
of the vagus more quickly than No. 12, and that No. ro (P. reti- 
rugis) was more effective than Nos. 9 or 12. It was further ob- 
served that the complete failure of the vagus nerve to cause inhi- 
bition differed with the different turtles used, although the in- 
fusions were applied in the same manner and with equal frequency. 
The rapidity of recovery of the vagus nerves from the Panaeolus 
infusions to a great extent depended upon the animal. 
Tests were made to determine the extent of the influence the 
infusion had on the nerve. The normal heart inhibitions were 
recorded on stimulating the vagi; then, as in the case of the frog, 
one of the nerves was painted with Panaeolus infusion at a point 
between the electrodes and the heart. The nerve was stimulated 
electrically at intervals of one minute. . When stimulation failed 
to produce inhibition the electrodes were moved to a point between 
the heart and the point of application of the infusion. In all cases 
stimulating at the new point caused inhibition. From such ex- 
periments, I am of the opinion that the Panaeolus infusion acts 
only locally. Painting the heart of the turtle with infusion abol- 
ished the vagus action. 
The similarity in the behavior of Panaeolus infusion to cocaine 
made it desirable to compare the two substances on the vagus of 
the same animal. After recording heart inhibitions from the 
right and the left vagus the former were painted with infusion 
No. 9, and the latter with .3 per cent cocaine. The results ob- 
tained were identical. With cocaine, however, the effect was more 
rapid and the recovery more slow than for Panaeolus infusion, 
although it must be borne in mind that the amount of the active 
