xevi Proceedings of the 
the cause of relapsing malaria. The cinchena alkaloids can be 
grouped into (¢) dextro- and (}) levo-rotatory groups, and the 
oes aed : songs against a pure strain of Paramecium 
caudatum, used a experimental protozoal animal was tested 
under cea ancy’ controlled conditions. Quinidine was found 
to be ten times as active as quinine and the dextro-rotatory alka- 
loids in general more active than the levo-rotatory. All cause 
muscle necrosis when given intramuscularly, and especially so if 
an acid salt be used The influence of the substrate is enormous, 
and a very slight alteration in the P,, of the porta! blood may 
render these alkaloids ten times as efficacious or ten times less 
efficacious. The moral is that the tentinont of malaria is not 
summed up in the one word ‘* quinine’’; quinidine or even 
cinchona febrifuge is far more efficacious and it should be so 
administered as to reach the portal blood stream at the moment 
of its most alkaline tide, a previous administration of 
alkalies may enhance its va 
Dr. K. K. Chatterji, EROS I., read a paper ‘* On Climatic 
Variations in Surgical Practice.’’ He showed that in Calcutta 
in the months of June to September the bacterial content of 
the atmosphere is at its maximum and that these were the 
worst months of the vear for surgical work. Special precau- 
tions against sepsis should be taken in operating theatres 
during these months. After cyclonic weather the bacterial 
content fell. 
r. U.N. Brahmachari, Rai Bahadur, M.A., M.D., Ph.D., 
KA s B. read a paper ‘ On the Influence of the ae and 
Basic Radicles of an Antimonyl Compound upon the Toxicity 
of its Antimony Content.” He pointed ont that of the 
antimonyl tartrates the toxicity of the ammonia-urea tartrate 
was the least, whilst the glycerides were still less toxic and non- 
hemolytic. Sb in pentavalent form was far less toxic than Sb 
in trivalent form. Hence his new preparation, urea aeeoeye 
seemed to be very promising in the treatment of kala-azar. 
Dr. Brahmachari’s new preparation has su ee been 
the subject of abe: reports by different workers in the 
medical journals, some of whom report it to be far m 
efficacious in the bisitncent ot kala-azar than are the saninany! 
tartrates 
—4—_ 
MAY, 1922. 
A meeting of the Medical Section of the Society was held 
on “aoe the 5th May, 1922. 
r. Upendranath ee achan, Rai Bahadur, M.A., M.D., 
Ph. D. F. A.S.B., in the chai 
