18 Hallier, 
bore to numerous manifestations of the disease. The cause of 
the difficulty in determining the mode of origin of the bile ducts, 
was seen to consist in their fragility and intimate association with 
the liver cells, each cell on being separated from its neighbors 
carrying with it its portion of biliary reticulum. The delicacy of 
the membrane forming the walls of the reticulum, renders its 
thorough injection impracticable, and its recognition, when empty, 
impossible. The brilliant tenacious secretion of the liver in this 
disease distends and reveals every portion of the biliary channels. 
The larger ducts between the acini can be recognized in every 
carefully prepared section communicating with the intra -lobular 
reticulum. Immediately after death, the yellow secretion begins 
to pass out of the reticulum by exosmose, and to tinge the liver 
cells with a diffused yellow coloration, so that it is difficult to 
preserve the biliary reticulum for anatomical demonstration. Plate 
6 represents the liver cells examined several hours after death. 
In other specimens the injection is more permanent, and I have 
been enabled to save for demonstration portions of diseased liver 
which still reveal the most marked phenomenon of the disease. 
The source of the bright yellow coloration of the bile was 
evidently in the haematoidine (Virchow) of the broken down blood- 
discs. The coagulating fibrin of the effused blood, absorbing this 
yellow dye, formed the characteristic flocculi of the bile; the same 
absorbed by the capillaries of the liver gave rise to the yellow 
flakes circulating with the blood, and found abundantly in the 
spleen. 
The mucous membrane of the hepatic duet was always of a 
bright crimson hue. 
In one instance, in which the injection of the reticulum of 
bile ducts was most marked and most permanent, there was no 
fatty degeneration of the enlarged liver, but a waxy appearance. 
2) The Kidneys. The kidneys, in every post-mortem that 
I witnessed were enlarged, deeply congested, black on the sur- 
face and in section, the cut surface giving issue to an abundance 
of dark blood. The natural distinction of color between cortical 
and tubular portion was effaced. The tubuli uriniferi of both the 
cortical and tubular portion were rendered opaque by a deposit 
of granules of fat in their epithelium, and their cavity was occu- 
pied, for the most part, by coagula, reddened or blackened by 
débris of blood corpuscles. and by granules of dark crimson pig- 
