Die Parasiten der Infectionskrankheiten. 19 
ment, with occasionally a recognizable blood dise. The Malpighian 
bodies were not affected, but blood was occasionally found effused 
within their capsule. The tubular presented the same alterations 
as the cortical portion. In one instance, in which the projecting 
cones of the tubular portion presented to the unassisted eye a 
elittering yellow coloration, it was due to rhomboidal plates and 
stellate crystals of haematoidine. Minute, yellow oily drops were occa- 
sionally found scattered through the epithelial lining of the tubes. 
An interesting alteration in the effused blood was noted 
in cases of long duration, and during convalescense. The red 
pigment within the tubuli was changed into melanine, and black 
pigment granules filled the epithelium of the tubuli. The trans- 
formation of haematoidine into melanine was beyond question. 
Long after every other morbid character had given place to heal- 
thy structure through convalescence, the cortical portion of the 
kidneys retained the black coloration due to granules of me- 
lanine. 
3) The Spleen. — Increased size and weight of the spleen was 
an invariable accompaniment of the disease. At the same time 
the consistence was diminished to such a degree that it gave issue 
to a soft black pulp on section, in which all trace of structural 
arrangement was lost. The increased size of the spleen was not 
due to congestion merely. A remarkable alteration was presented 
by the nuclear and cellular elements of the parenchyma. The 
nuclei (nuclear epithelium, Robin), or the same with delicate cel- 
lular investment, which in the natural state, fill the closed vesi- 
cles of the Malpighian bodies and the trabecular interspaces, were 
replaced by the large cells undergoing fatty degeneration, which 
have been represented in Plate 8. In some instances, yellow floc- 
culi were found free in the splenic pulp; in others, cells filled 
with black pigment granules and crystals of haematoidine were 
abundant. The appearance presented in Plate 9 always accom- 
panied convalescence. The cellular elements rapidly regained their 
normal character, but the pulp was filled with minute homoge- 
neous rounded yellow granules, or with spherical or oval aggre- 
gations of the same. 
4) The mucous membranes of the fourth stomach and intesti- 
nes, and of the urinary and gall bladders, presented a difiused 
redness, with minute petechial spots, in which coagulated blood 
was found filling the distended capillaries. The epithelia of these 
DES 
