40 Hallier, 
confirmed the medical opinion of the profession that the most 
constant of any of the anatomical changes in the latter- malady, 
is found in the liver, and in a certain kind of coloration which 
attends the malady as a resultant of the dissolution of blood glo- 
bules. Whoever peruses this report, should, if possible, read the 
Prize Essay of Dr. Speir in the Transactions of the American 
Medical Association (vol. XV, 1864), and consult the letter from 
Prof. Clark in the first volume of Dr. La Roche, on yellow 
fewer and the report on yellow fever in Lisbon in 1858 by Dr. 
Robert Lyon. These distinguished pathologists found that the 
pestilential destruction of blood globules, the presence olf the re- 
sulting haematoidine, or of haematine, from which it is derived, 
and the acute fatty change in the_ultimate structure of the liver, 
are the most essential pathological events in that malady. But 
the opportunity for studying the structural (morphological) altera- 
tions in the liver, the blood, the spleen and the kidneys in fatal 
cases of yellow fever, have not given the facilities for precision 
in results of microscopical inquiry (because not made in every 
stage of the disease and of convalescence, and before any post- 
mortem change was possible) which have been afforded by the in- 
fected cattle for the examination of these vital structures. And 
it is one of the rewards of the latter class of labors that they 
elucidate and verify the chief deductions that have been made by 
the learned physicians whose researches in yellow fever are here 
mentioned. 
In concluding this brief note upon the aid given to clearer 
demonstrations in pathology by these investigations, we would not 
omit to notice the very instructive researches of the late Dr. 
Daniel Blair, chief medical officer of the British military esta- 
blishment in Demerara; for when he died in the midst of great 
efforts to discover the true cause of yellow fever, sanitary sciense 
lost its most ardent inquirer into the natural causes of this pesti- 
lence. The latest of his observations were so directly in the 
line of the demonstrations that have resulted from Dr. Stiles’ 
investigations that we mention them in this place. Truly scien- 
tific physicians are jealous only for the truth; and it will be 
noticed that Dr. Blair reached the verge of that important dis- 
covery which Dr. Stiles has made in regard to the actual ulti- 
mate structure of the biliary system. It was in a living patient 
in his hospital, and in some vomited bilious and bloody matter 
