THE CHEMISTRY OF VENOMS. 



19 



II. Copper-venom-globulin. 



Boiling 



Sodic chloride (10 per cent.) 



Carbonic acid 



Sodic carbonate 



Hydrochloric acid (0.4 p. c.) 



Metaphosphoric acid 



Orth opkosphoric acid 



Sodic melaphosphate 



Sodic orthophosphate 



Potassic sulphate 



Calcic chloride 



Acetic acid (5 per cent.) 



Acetic acid (glacial) 



Crotalus horridus. 



Coagulates 



Insoluble 



Insoluble 



Very soluble 



Very soluble 



Insoluble 

 Very soluble 

 Insoluble 

 Soluble 

 Insoluble 

 Soluble 

 Soluble 

 Soluble 



Ancistrodou piscivorus. 



Apparently dissolves. 



Insoluble. 



Somewhat soluble. 



Very soluble. 



Very soluble. 



Insoluble. 

 Very soluble. 

 Insoluble. 

 Soluble. 

 Insoluble. 

 Insoluble. 

 Soluble. 

 Soluble. 



III. Dialysis-venom-globulin. 



Reagent. 



Boiling 



Sodic chloride (10 per cent.) 



Carbonic acid 



Sodic carbonate 



Hydrochloric acid (0.4 p. c.) 



Metaphosphoric acid 



Orthophosphoric acid 



Sodic mctaphosphate 



Sodic orthophosphate 



Potassic sulphate 



Calcic chloride 



Acetic acid (5 per cent.) 



Acetic acid (glacial) 



Crotalus adamantrus. 



Coagulation 

 Somewhat soluble 



Soluble 

 Very soluble 

 Very soluble 



Insoluble 

 Very soluble 

 Very soluble 



Soluble 



Insoluble 



Soluble 



Soluble 



Soluble 



Ancistrodou piscivorus. 



No coagulation ? 



Somewhat soluble. 



Very soluble. 



Very soluble. 



Very soluble. 



Slightly soluble. 



Very soluble. 



Insoluble. 



Soluble. 



Slightly soluble. 



Very soluble. 



Soluble. 



Soluble. 



It will be noticed by a careful comparison that the corresponding principles in 

 different venoms differ quite as much from each other as the globulins in any one 

 variety of venom. 



Venom Peptones.— We have not been able to detect any chemical differences 

 in the venom peptones of the Crotalus and Ancistrodon. Cobra venom peptone 

 is distinguished from that of the Crotalus and Ancistrodon by its non-precipita- 

 bility by mercuric chloride and absolute alcohol. 



Daboia Venom.— We have had a small quantity (a few grains) of Daboia venom 

 at our disposal, but too little to attempt any detailed chemical investigations. In 

 two examinations, however, with very small quantities, we separated two bodies 

 corresponding to those in Cobra, that is a water-venom-globulin and a peptone. The 

 former exists in exceedingly small quantity while the latter dialyses with appa- 

 rently much more difficulty than that of the Cobra. 



The Proportions of Proteid Constituents in Different Venoms.— An examination 

 of o-ood specimens of the dried venoms of the Crotalus adamanteus, Ancistrodon 

 jriscivorus, and Cobra gives us the following proportions of the globulins and 

 peptones : — 



