GLOBULINS AND PEPTONES AS LOCAL POISONS. 55 



globulins, all of which bring about essentially the same local alterations. To 

 fully satisfy ourselves that these interesting local effects were dependent upon 

 the physiological activities of the globulins and not upon a possible contamination 

 by peptone, observations were made with the boiled globulins. In none were 

 there the least evidences of the presence of any poisonous element. 



Whevever globulins alone are used, we have these local bleedings, fluid blood, 

 and capillaries giving way soon after the poison reaches them. The system at 

 large soon or late repeats the coarser phenomena of the wound ; and yielding 

 vessel walls, fluid blood, and countless hemorrhagic outflows exhibit the power of 

 the globulins. Peptone, or, which is much the same, briefly-boiled venom, causes 

 putrefactive changes swiftly, and shows but slight capacity to make fluid the blood, 

 or to corrode the capillaries. The wound is foul and (Edematous, but not filled 

 with blood, whilst in its general effects the venom peptone fails again to exhibit 

 the capacity of the globulins to multiply hemorrhages, and to destroy the natural 

 ability of the blood by clotting to check its own wasteful expenditure. 



In proportion as the peptones predominate will we have then a lessening of 

 rapidly formed local lesions, and this is of course why Cobra venom does not give 

 us the same terrible local consequences which ensue in Daboia, Moccasin, and 

 Crotalus bites, where we have the potent combination of enough peptones and an 

 excess of globulins. For a comparison of the local effects of Cobra and Crotalus 

 poisoning, see Plate II., Figs. 2 and 3. 



