THE ACTION OP VENOMS UPON THE PULSE-RATE. 



57 



factory experiment, there was a decrease, and in six experiments with the Cobra 

 there was an increase in all, the increase being followed in three by a permanent 

 decrease; in one the increase was followed by a diminution, and this in turn by an 

 increase ; in two experiments there was a permanent increase, excepting near death 

 when a decrease ensued. 



It will thus be clear that even under apparently the same conditions we cannot 

 foretell what the alterations in the pulse-rate will be in any given experiment ; 

 although the results of the six experiments with Cobra venom are so uniform in 

 regard to the primary increase as to indicate that with it at least we should always 

 expect to find more or less acceleration which may or may not continue above 

 normal, even up to the time of death. 



We may also add here, that we cannot trace any relations in the alterations in 

 the pulse, arterial pressure, and respiration to each other, so that it seems as if 

 the changes must depend essentially upon actions peculiar to each apparatus. 

 This holds good with the study of the pure venoms or their isolated poisons. 



Action of the Pure Venoms upon the Pulse-rate in Normal Animals. 

 Experiment No. 1. 



Normal 



Time: 



Pulsations 





min. 



sec. 



per minute. 









285 



Injected 1 dro 





20 



285 



into the thi«j 





40 



285 





1 



00 



285 





i 



20 



285 





] 



40 



285 





2 



00 



1 



Clot in canula. 



5 



00 



285 





7 



00 



285 





8 



00 



285 





9 



00 



270 





10 



00 



270 





11 



00 



240 





12 



00 



255 





13 



00 



270 





20 



00 



270 





21 



30 



270 





23 



00 



270 



At 1:00 the 



Injected 1 drop of fresh venom from the Crotalus adamanteus 



At 1:00 the blood-pressure began falling and reached a 

 minimum at 10:00, when it was one-third less than the 

 normal. 



REMARKS. 



Experiment No. 2. 



Time : Pulsations 



min. sec. per minute. 



Nomial ■•• 240 Injected 3 drops of the fresh venom of the Crotalus adaman- 



20 240 tens into the thigh of a large rabbit, 



40 240 



1 00 195 



1 20 

 8 April, 1886. 



Animal broke loose and tore the canula from the artery. 



