112 



THE VENOMS OF CERTAIN THANATOPHIDEJE. 



From this series of experiments with globulins it seems clear that they possess 

 the peculiar physiological effects of pure venoms upon the blood pressure; that the 

 water-venom-globulin is the most powerful, and the copper-venom-globulin the 

 least so, and that the copper-venom-globulin seems to exhibit a more marked 

 tendency than the others to cause a rise of pressure. 



Section III. — The Action of Venom Peptones upon the Blood Pressure. 



The Action of Venom Peptones upon the Blood Pressure of Normal Animals. — 

 Seven experiments were made with the peptones from different venoms : two with 

 that of Crotalus adamanteus ; three with Ancistrodon piscivorus; and two with 

 Cobra. The action of peptones upon the blood pressure is similar to that observed 

 with the pure venom and the globulins, but their power to cause the primary pro- 

 found fall of pressure is certainly much less, while the rise of pressure after the 

 primary fall is decidedly more marked, and there is also a tendency to go above the 

 normal. In two experiments, one with the peptone of the Crotalus and one with 

 that of the Moccasin, the pressure was not primarily reduced, but there was a rise 

 above the normal from the first. Where the animal was watched until death the 

 pressure was observed to undergo a more or less gradual decline with feeble heart- 

 beats. In several instances a rise of pressure was noted which was usually due to 

 convulsive seizures. 



Experiment No. 63. 



Normal 



Time: 



Pressure 



min. sec. 



m. m. 





140 



10 



128 



20 



128 



30 



136 



40 



128 



50 



128 



1 00 



124 



11 00 



116 



21 00 



116 



Injected intravenously the peptone from 0.015 gram dried 

 venom of the Crotalus adamanteus. 



49 



Experiment No. 64. 



Normal 



Time: 



Pressure 



min. sec. 



m. m. 





114 



10 



130 



30 



132 



1 00 



120 



2 00 



140 



5 00 



144 



9 00 



124 



Clot. 



Dead. No ecchymoses ; lungs seem congested ; blood clots 

 readily. 



Injected intravenously the peptone from 0.03 gram dried 

 venom of the Crotalus adamanteus. 



Killed. Ecchymoses in the lungs ; blood clots. 



