118 



THE VENOMS OF CERTAIN T H AN A T P HI D E M. 



Experiment No. 78. 



Normal 



mill. 



sec. 



m. m, 



38 





11 



39 





20 



41 





40 



40 



1 



40 



35 



5 



40 



35 



10 



40 



3T 



15 



40 



38 



16 



00 





16 



06 



38 



16 



15 



38 



16 



25 



43 



16 



45 



43 



It 



00 



43 



18 



00 



40 



20 



00 



25 



23 



00 





Injected intravenously the peptone from 0.015 gram dried 

 Cobra venom. 



[■ Injected a similar dose. 



Dead. 



From all of the results of these experiments it seems justifiable to conclude that 

 the isolated principles of venoms exert the poisonous actions of pure venoms on 

 the blood pressure, and that their toxic effects are essentially simply different in 

 degree. These various poisons all play a part in the alterations of pressure, acting 

 towards the same end, but mainly with different degrees of intensity ; the water' 

 venom-globulin appears to be the most potent in the pressure alterations, the dialy- 

 sis-venom-globulin next, then the peptone, and finally the copper-venom-globulin. 

 The globulins are the more active in the production of the diminution of pressure, 

 and the peptone in the secondary rise. 



The globulins no doubt play a very important part in the poisonous phenomena 

 of Crotalus poisoning, a less important part in Aneistrodon poisoning, and but very 

 little in Cobra poisoning; these differences not depending as much upon differences 

 in the quality of the globulins in the species of venom to which they belong as on 

 differences in quantity. 



