THE ACTION OF YE NO MS UPON RESPIRATION. 



125 



lation, and probably due to some secondary cause, which is likely to be located in 

 the profound alteration of the blood or the destructive action of the venom upon 

 the pulmonary tissues, as illustrated, for instance, upon capillaries. 



Section II. — The Action of Globulins on the Respirations. 



The Action of Venom Globulins upon the Respiration in Normal Animals. — 

 Seven experiments were made with globulins upon normal animals : three with the 

 water-venom-globulin of the Crotalus adamanteus ; and one with the icater-venom- 

 globulin of Cobra; one with the copper-venom-globulin, and one with dialy sis-venom- 

 globulin, both from the Crotalus adamanteus. 



These poisons, excepting the copper-venom-glolndin, all act like the pure venoms, 

 but generally with a less degree of intensity, causing a primary acceleration of the 

 respiration followed by a decline. In the second experiment, however, there was 

 no diminution, but the respirations became enormously increased so that at death 

 they were nearly trebled in frequency. The copper-venom-globulin does not cause 

 any primary acceleration, but simply a diminution. 



Experiment No. 16. 



Normal 



Length of 



Time: 



Respirations 



curv 



min. see. 



per minute. 



m. n 





100 



9 



20 



100 



15 



40 



100 



12 



1 00 



96 



11 



3 00 



96 



9 



4 00 



120 



10 



5 00 



120 



10 



G 00 



132 



10 



8 00 



100 



10 



10 00 



90 



9 



12 00 



80 



9 



14 00 



69 



1 



14 05 







14 20 



80 



15 



14 40 



60 



10 



16 40 



90 



10 



18 40 



96 



8 



20 40 



108 



9 



22 40 



114 



9 



24 40 



108 



9 



26 40 



90 



6 



28 40 



96 



8 



30 40 



72 



7 



32 40 



64 



8 



34 40 



70 



8 



36 40 



75 



8 



38 40 



80 



9 



40 40 



90 



10 



44 00 







Injected intravenously the water-venom-globulin from 

 0.015 gram dried venom of the Crotalus adamanteus. 



Injected as above from 0.06 gram dried venom. 

 Stru»-£cles. 



Dead. Heart arrested in diastole ; some eechymoses. 



