THE ACTION OF VENOMS UPON RESPIRATION. 



129 



The Action of Venom Globulins on the Respiration of Animals in which the 

 Pneumogastric Nerves were Cut. — Two experiments were made on animals with 

 cut pneumogastric nerves : one with the dialysis-venom-globulin, and one with the 

 copper-venom-globidin, both from the Crotahts adamanteus. 



In neither experiment was there an increase in the respirations ; these results 

 bein" 1 in accord with the experiments made with pure venom. 



Experiment No. 23 



Normal 



Time: 

 min. see. 



Respirations 

 per minute. 

 42 



Length of 



curve 



m. m. 



8 



10 



39 



10 



20 



30 



12 



40 



24 



8 



1 00 



27 



10 



1 20 



? 





3 20 



20 



9 



5 20 



35 



8 



8 20 



24 



5 



18 20 



30 



5 



23 20 



32 



6 



36 20 



42 



7 



36 40 



42 



7 



38 40 



24 



20 



42 00 







Experiment No. 24. 



Normal 



Time: 

 min. sec. 



Respirations 



per minute. 



60 



Length of 



curve 



m. m. 



5 





30 





54 



6 



1 



00 





48 



5 



3 



00 





48 



5 



8 



00 





,48 



5 



13 



00 





52 



6 



15 



00 





48 



6 



15 



30 





30 



4 



15 



40 





54 



15 



16 



00 





? 





16 



30 





18 



10 



19 



00 





12 



4 



24 



00 





20 



4 



27 



00 





20 



5 



30 



00 





30 



5 



35 



00 





26 



5 



39 



00 





27 



5 



41 



00 





30 



5 



44 



00 





42 



6 



49 



00 





30 



6 



54 



00 









17 



June, 



1886, 







Pneumogastric nerves previously cut. Injected hypo- 

 dermically the dialysis-venom-globulin from 0.015 

 gram dried venom of the Crotalus adamanteus. 



Struggles. 



Injected dialysis-venom-globulin from 0.06 gram.' 



Struggles. 



Respiration ceased; heart beats feebly; blood remains 

 incoagulable; great ecchymoses in abdominal viscera. 



Pneumogastric nerves previously cut. Injected intra- 

 venously the copper-venom-globulin from 0.015 gram 

 dried venom of the Crotalus adamanteus. 



Injected copper-venom-globulin from 0.03 gram dried 

 venom in two doses. 



j Struggles with very irregular breathing followed by 

 1 gasping respiration. 



Injected copper-venom-globulin from 0.12 gram dried 



venom in two doses. 

 Respiration ceased ; heart still beats ; ecchymoses in 



heart and lungs marked. 



