THE ACTION OF VENOMS UPON RESPIRATION. 



131 



Experiment No. 27. 



Normal 



Time: 

 min. sec. 



Respirations 

 per minute. 



75 



Length of 



curve 



m. m. 



9 



10 





120 



42 



3 00 





30 



10 



6 00 





75 



8 



11 00 





50 



8 



18 00 





48 



7 



23 00 





50 



7 



28 00 





45 



7 



33 00 





60 



7 



37 00 





60 



9 



49 









Injected intravenously the peptone from 0.015 gram 

 dried venom of the Crotaluts adamanteus. 



Dead. No ecchymoses; lungs slightly congested. 



In one animal the increase was equal to one-third of the normal; in the second, 

 in which a larger dose was used, the normal rate wa& doubled ; and in the third 

 it rose to more than one-half of the normal. There was not, however, in any of 

 the animals that marked depression which is observed in poisoning with pure 

 venom or venom globulins. 



The Action of Venom Peptones on the Respiration in Animals in which the 

 Pneumogastric Nerves had been previously Divided. — In one experiment in which 

 the pneumogastric nerves were cut and in which the peptone from the venom of 

 the Grotalus adamanteus was used,, the well-marked primary increase in the respi- 

 rations did not occur, there being a diminution from the first. 



Experiment No. 28. 



Normal 







Length of 



Time: 



Respirations 



curve 



min. sec. 



per minute. 



m. m. 





80 



13 



10 



52 



18 



15 



37 



12 



20 



25 



8 



30 



22 



7 



1 00 



30 



8 



1 30 



30 



7 



3 30 



40 



9 



8 30 



60 



8 



15 30 



36 



13 



20 30 



48 



17 



25 30 



50 



14 



30 30 



52 



15 



35 00 



55 



12 



40 00 



48 



15 



45 00 



45 



15 



50 00 



45 



16 



62 00 



44 



15 



Injected intravenously the peptone from 0.015 gram 

 dried venom of the Grotalus adamanteus, 



Struggles. 



Killed by pithing. 



In this experiment, as in those with pure venom and venom globulins in which 

 the animals had the pneumogastrics cut, the increased respiration rate seen in 

 normal animals did not occur. 



