PATHOLOGY. 



147 



by the presence of extravasated blood. The changes described are not uniform, 

 even in an individually affected fibre, but are bounded by small abrupt layers of 



Fig. 3. 



normal sarcous elements, the whole being surrounded by an unaffected sarco- 

 lemma. The latter, which is beautifully demonstrated on such occasions, shows 

 constrictions in those places where the sarcous elements are disintegrated. (See 

 Figs. 3 and 4.) 



Fig. 4. 



All muscular fibres of the part Avhere the poison was injected are more or less 

 granular, and are often stained by hematin. The granular material between the 

 fibres has very much the appearance of micrococci, but by appropriate tests only a 

 small proportion of the granules can be identified as bacteria. The remaining 

 granular matter can be identified as particles of necrosed sarcous elements, dis- 

 integrated blood, and granular substances which have been described as constituents 

 of the fresh venom and introduced from without. These granular muscle changes 

 occur only in or near the wound, and not also in remote muscles. They demand 

 for their production a certain length of time, and are most decided in cases of long 

 survival. 



Changes in the Lungs. — As has been seen from the table of experiments, the 

 injection of venom into the lungs was followed by nearly instantaneous death. 

 The local lesion was an hemorrhagic infarction throughout the whole of the paren- 



