HEPATOZOON. 153 



89. Hepatozoon leporis (Patton). 



■fLeucocytozoon leporis, Patton, 1908, p. 319. 

 Hepatozoon leporis, Wenyon, 1926, p. 1359. 



Patton (1908) merely recorded this as a new species, without 

 giving any description. 



Habitat. — Blood of the black-naped hare, Lepus nigricollis 

 (Cuvier) : Madras, Madras. 



90. Hepatozoon muris (Balfour). (Fig. 70.) 



Leucocytozoon muris, Balfour, 1905, pp. 110-11, pi. xi. 

 ^Leucocytozoon ratti, Adie, 1906, pp. 325-6, text-figs. 



Hepatozoon perniciosiim. Miller, 1908, pp. 1-48, pis. 



Hepatozoon muris, Minchin, 1912, pp. 376, 377. 



Heemogregarine ratti, Castellani & Chalmers, 1919, p. 486. 



Hepatozoon tnurts, Wenyon, 1926, pp. 1085, 1086-90, fig. 453, pi. xix, 



figs. 1, 2. 

 '\Hepatozoon muris, Donovan (recorded in Wenyon, 1926, p. 1360). 



Hepatozoon muris, Reichenow, 1929, pp. 920-1 ; Kudo, 1931, 

 p. 282, fig. 119, A;. 



Schizogony takes place in the hver-cells of a rat. Smallest 

 schizont is a spherical, uninucleate body. The schizont 

 increases in size, and the nuclei multiply by repeated division 

 till there are 12 to 20. The full-grown schizont is surrounded 

 by a delicate cyst-wall. Merozoites are budded off, enter 

 other cells, and repeat schizogony. After a time the merozoites 

 become young gametocytes, enter the blood-vessels, invade 

 the mononuclear leucocytes, and appear as Hsemogregarines. 

 When the blood is sucked by the mite, Leelaps echidninus, 

 the Hsemogregarines are hberated from the leucocytes and 

 escape from the enclosing cysts. The gametocytes associate 

 in pairs, each becoming flattened to produce an elongated 

 body, with pointed extremities. Complete fusion of the two 

 gametocytes is said to take place. Before actual union takes 

 place the macrogametocyte increases somewhat in size and 

 encloses the smaller microgametocyte. After fertilization 

 the zygote elongates and becomes a motile ookinete ; this 

 moves about in the stomach-contents, increasing in size. 

 Later it penetrates through the intestinal wall and settles 

 down in the surrounding tissue, becoming spherical and growing. 



escaping from mononuclear cells in the stomach of the mite ; 

 L-0, syngamy and penetration of intestinal wall by zygote 

 (ookinete) ; P—S, growth of zygote (sporont) in oocyst 

 in tissues of mite ; T, surface of sporont, showing sporoblast 

 formation by budding ; U, portion of oocyst containing 

 sporoblasts ; V, portion of oocyst containing sporoblasts 

 with multiplying nuclei ; W, portion of oocyst containing 

 sporocysts in each of which are a number of sporozoites. 

 The mite is eaten by the rat, in the intestine of which the 

 sporozoites escape from the sporocysts. (From Wenyon, 

 after Miller.) 



