ANAPLASMA. 325 



Remarks. — De Mello found these bodies in the blood-corpuscles 

 of a man who had never been outside India, but it is doubtful 

 if the so-called " Seidehn bodies " are an independent organism. 



Habitat. — Blood of man : Portugubsb India, Nova Goa. 



Genus ANAPLASMA Theiler, 1910. 



" Marginal points," Smith & Kilborne, 1893, p. 177. 



Anaplasma, Theiler, 1910, pp. 135-7 ; 1912 a, pp. 319-38 ; 1912 6, 

 pp. 105-16; 1912 c, pp. 193-207; Minchin, 1912, p. 383; 

 Dias & Aragao, 1914, pp. 231-49 ; Carpano, 1914, pp. 42-53 ; 

 Lignieres, 1914, pp. 133-62; 1919 a, pp. 558-66; 1919 b, 

 pp. 641-51 ; 1919 c, pp. 774-9 ; Hegner & Taliaferro, 1924, 

 pp. 305-6 ; Wenyon, 1926, pp. 1053-6 ; Knowles, 1928, pp. 466-7. 



Spherical body of chromatin less than 0-5//, in diameter, 

 situated at or near the edge or towards the centre of the red 

 blood -corpuscles. Infection transmitted by a tick. 



Remarks. — Smith and KLilborne (1893) in their studies on 

 Texas fever of cattle recognized certain red-staining granules 

 on the margin of red corpuscles (" marginal points ") and 

 regarded them as a resistant phase of Babesia bigemina. 

 Theiler (1910) recognized similar bodies in the blood of cattle 

 in South Africa, and referred them to Anaplasma, a new 

 genus of parasitic Protozoa. The bodies are commonly found 

 in association with infections of B. bigemina and B. mutans, 

 and Carpano (1914) considered them as resistant forms of 

 Piroplasmata. Dias and Aragao (1914) beheved that they are 

 not true organisms at all, but a hsemolytic product. Theiler 

 (1912) and Lignieres (1919) have described cases of pure 

 infection with these bodies. According to the latter author, 

 in true Anaplasma infections as many as 50 per cent, of the 

 red corpuscles may be infected, and the infection is readily 

 transmissible to clean cattle. Infected cattle suffer from 

 fever and an intense and progressive anaemia. Laveran and 

 Franchini (1914) discovered them in numerous Mammals, 

 such as rats, mice, rabbits, guinea-pigs, moles, cats, dogs, 

 calves, pigs, and monkeys. De Mello and his colleagues (1917) 

 found them in human blood, and also in the blood of fishes, 

 frogs, lizards, snakes, and birds, but did not regard them as 

 Protozoa, considering them to be hsemolytic products. 



272. Anasplasma sp. (Fig. 161.) 



■\ Anaplasma, de Mello, de Sa, de Sousa, Dias, & Noronha, 1917, 

 pp. 17-21, pi. ii, figs. 21-9. 



Intra-corpuscular, oval or lanceolate, of small dimensions, 

 and staining like chromatin ; apparently not possessing 

 any cytoplasm. 



