57 

 blood serum for animal 1 also exhibited this mustard color 

 which turned to red on d 78. In contrast, animal 46 did not 

 show any abnormal color changes . 



Animal 1 had a very high liver Cu concentration (Table 5- 

 1) which might have been expected since that animal had 

 received the high Cu diet for 78 d. All other animals (46, 77 

 and 288) had relatively similar liver Cu levels. Kidney Cu 

 levels varied with animal 1 having the highest (846 mg/kg) and 

 animal 288 having the lowest (32 mg/kg) . 



Liver Zn concentrations (Table 5-2) were higher for 

 animals 1 (CuLys) and 77 (CuS0 4 ) , the animals suspected of 

 developing a full-blown Cu toxicosis. Kidney Zn 

 concentrations were very similar for all animals. 



The necropsy report for animal 1 (CuLys), slaughtered on 

 d 78, indicated a mild chronic multifocal bronchopneumonia 

 with aspirated foreign material. Also, severe chronic 

 cholangiohepatitis , severe chronic periportal 



TABLE 5-1. Liver and kidney Cu concentrations of 

 sheep exposed to high Cu levels 3 . 



Animal # Liver (mg/kg) Kidney (mg/kgi 



1 (CuLys) 2552 846 



46 (CuLys) 985 530 



77 (CuS0 4 ) 1036 426 



288 (CuS0 4 ) 937 32 



Dry matter basis 



