58 



TABLE 5-2. Liver and kidney Zn concentrations of 

 sheep exposed to high Cu levels 3 . 



Animal # Liver (mg/kg) Kidney (mg/kg) 



1 (CuLys) 191 117 



46 (CuLys) 90 123 



77 (CuS0 4 ) 168 126 



288 (CuSOJ 107 122 



a Dry matter basis. 



and centrilobular hepatocyte necrosis and histiocytic 

 hyperplasia with megalocytosis , biliary hyperplasia and portal 

 fibrosis were observed in the liver. In the kidney a mild 

 chronic lymphocytic pyelonephritis with scattered tubular 

 casts was reported. The absence of hemoglobinuric nephrosis 

 suggested that the Cu accumulation in the liver was 

 subclinical at the time of death. 



The necropsy report for the liver of animal 46 (CuLys), 

 slaughtered on d 41, showed an overall reduction of 

 hepatocytes and increased fibrous stroma. There was also 

 severe autolysis and biliary stasis. The report for the liver 

 of animal 77 (CuS0 4 ) , which died on d 30, showed a severe, 

 diffuse hepatopathy with cytoplasmic Cu accumulation and 

 individual hepatocyte necrosis. Also there was a severe, 

 intrahepatic cholestasis and a mild, multifocal, suppurative, 

 acute hepatitis. The pathological report for animal 288 

 (CuS0 4 ) , slaughtered on d 78, indicated severe chronic 

 multifocal dystrophic mineralization, fibrosis, and 



