61 

 Results of this study do not indicate CuLys to be more or 

 less toxic than CuS0 4 . These data do indicate that there were 

 some plateaus in the different serum enzyme and Cu 

 concentrations for those animals receiving CuLys, which were 

 not present with animal 77. 



Implications 



The use of high Cu supplementation in sheep, from this 

 small scale study, and the development of toxicity is not 

 dependant on the source used. The supplementation of CuLys as 

 a source of "safe" Cu when supplemented in excess is 

 inconclusive and needs to be further researched. 



Summary and Conclusions 



A study was conducted to compare toxicity of CuLys and 

 CuS0 4 when supplemented at concentrations that would cause a 

 chronic toxicity to sheep. Four animals, 3 crossbred wethers 

 and 1 crossbred ewe averaging 4 6 kg were randomly assigned to 

 250 mg of supplemental Cu from either CuLys or CuS0 4 . Lambs 

 were fed the treatment diets for 4-11 wks following a 7 d 

 adjustment period. Blood samples were taken on d 1 before 

 animals were administered the concentrate and biweekly 

 thereafter. Serum and blood samples were analyzed for CK, 

 GGT, AST, HCT, and heinz bodies. Sections of liver and kidney 

 were excised and necropsied, and together with serum and diet 

 were analyzed for Cu and Zn . The liver and kidneys of animal 



