849 
jep. 38. Liquid: 0.8 ee. 5°/, cocain solution and 4.2 ec. extract 
of dried cat’s brains, thus containing 1°/, cocain. 
| Reading taken of 
inductorium (E’) 
Stimulation after: Control (E”) 
| 
Dati 1.8 1.8 
4 | == == 
46 1.8 1.8 
48 1.7 1.8 
50 | 1.7 1.8 
52 1.68 1.8 
54 1.6 1.8 
56 | 1.5 1.8 
58 | 1.42 1.8 
60 | 1.3 1.8 
62 1.1 1.8 
64 cs 1.8 
Result: This extract proves to possess distinct inhibiting power, 
since only after 64 minutes the nerve becomes irresponsive (normally 
after 22 minutes). 
CONCLUSIONS. 
1. Our experiments produced evidence for our assertion that the 
action of cocain can be considerably inhibited by the addition of: 
a. the serum of man, dog, rabbit and cavia; 
4. the brain-substance of rabbit and cat; 
c. ether-extract of dried cat’s brains; 
d. \ecithin. 
He's and SANo’s experiments are hereby supported and extended. 
2. This inhibition of cocain, is not brought about by a chemical 
decomposition of the cocain but by a physical adsorption; for, 
through extraction with hydrochloric acid and aleohol of a mixture 
with a reduced cocain action, all the cocain can be restored, which 
has still retained its activity. The melting point of this cocain also 
lies very near to normal values. 
3. Serum, brain-substance and lecithin are of themselves not 
deleterious to the frog’s nerve, nor when these materials (in control 
experiments) were extracted with hydrochloric acid and alcohol. 
56% 
