922 
In fig. 5 0.01 mgr. of pilocarpin had a distinct action (a), which 
became slightly less, when pilocarpin was given the second time 
(6). Then the gut was washed out in 150 ce. of Tyrode, to which 
1 ce. of 1°’, cerebron-emulsion was added. Then the gut was removed 
to the vessel of 75 ec. Tyrode and again 0.01 mgr. of pilocarpin 
was added (c); the subsequent contraction was obviously larger than 
before. 
The process of the experiment of Fig. 6 was different; 0.01 mgr. 
of pilocarpin yielded a distinct action (a); after this dosis had been 
washed out 0.01 mer. of pilocarpin was administered that bad been 
dissolved for more than an hour in a 1°/, cerebron emulsion, (0); 
the subsequent contraction of the gut was of precisely the same 
magnitude as before, which proves, therefore, that cerebron does 
not inhibit the action of pilocarpin. After the pilocarpin + cerebron 
had been washed out, again 0.01 mgr. of pilocarpin was given (c), 
which, as in Fig. 5, yielded a greater contraction than before. 
The same result was achieved in a third experiment with cerebron. 
Influence of Witte's peptone on the action of pilocarpin upon 
the gut. 
As in the case of cerebron two points had to be settled also regard- 
ing peptone viz. the capacity of adsorbing pilocarpin and of inten- 
sifying the action of pilocarpin. We deemed it possible that Witte’s 
peptone (a mixture of albumoses) might adsorb pilocarpin, because 
ABEL *) has shown recently that albumoses occur in normal serum, 
which in themselves are not poisonous, but are capable of adsorbing 
poisonous substances. 
The investigation of “peptone” proceeded in the same way as 
that of cerebron. The adsorptive property of peptone appeared to 
be very weak, but its intensifying effect on the pilocarpin-action is 
most strongly marked, as shown in fig. 7. 
In the experiment illustrated by this figure 0.05 mgrm of pilo- 
carpin was administered three times running (a, 6, c), and the sub- 
sequent deflections of the gut were exactly the same in these three 
cases; after the pilocarpin had been washed out and the gut was 
again put back in the vessel of 75 eem, '/, ce. 1 °/, Witte's peptone 
was added to this vessel to demonstrate that this substance of itself 
1, J. ABEL. On the presence of histamin (@-iminazolylethyl amin) in the 
hypophysis cerebri and other tissues of the body and its occurrence among the 
hydrolitie decomposition of proteins. Proc. Amer. Soc. for pharm. and exp. 
Therap. Journ. Pharm. and exp. Ther. vol. XIII, p. 511. 1919. 
