923 
did not exert any influence upon the gut (d). Subsequently, again 
0.05 mer. of pilocarpin was added, and the following contraction is 
much larger than before the addition of peptone. After this had 
been washed out again 0.05 mgr. of pilocarpin was given. This, 
however, had been mixed an hour before with a 1 °/, peptone-solu- 
tion, and the result was a weaker action of the pilocarpin than 
before (7), so that the peptone must be assumed to have adsorbed 
a small portion of the pilocarpin. After this had been washed out 
pilocarpin alone was given again twice (g and h). In both cases the 
action of pilocarpin was increasing, which proves conclusively that 
the peptone possesses in a marked degree the property of intensi- 
fying the pilocarpin-action. This experiment also gives evidence that 
peptone is capable of exerting this action 1 when both peptone 
and pilocarpin are in contact with the gut and 2 when the peptone 
has first been in contact with the gut, and is subsequently washed out. 
In all we performed 16 experiments witb peptone, in 5 of which 
the pilocarpin-action after the peptone was much stronger than 
before; 7 times the action was appreciably stronger; twice slightly 
stronger; twice equal and in only one case it was weaker. How- 
ever in this case it got stronger again after adding pilocarpine a 
few times, so that in 14 out of 16 cases peptone had an intensifyng 
influence upon pilocarpin. 
While this investigation was in progress, it appeared from other 
inguiries performed in this institute that peptone does not only in- 
tensify the pilocarpin-action on the gut but under certain conditions 
also intensifies the action of adrenalin upon the blood-pressure in 
the cat. In this inquiry we also detected that a similar effect was 
produced also by a dialysate of peptone. This induced us to investigate 
these dialysates also with respect to their effect upon the gut, which 
to our surprise proved to be different from that of peptone itself. 
This effect of the “peptone” dialysate is manifest in fig. 8. In 
the experiment which it illustrates first 0.1 mgr. of pilocarpin is 
given some times running (a,b,c). The effect was the same every 
time. Then the gut was washed out not in a pure Tyrode-solution, 
but in one that contained a small quantum of dialysate, viz. a 
quantum that on analysis proved to contain 0,125 mgr. of nitrogen. 
In fig. 8 it may clearly be seen that the consequence of it was 
that the subsequent pilocarpin dosis had a weaker effect than before 
dj. After the action of the pilocarpin had continued for 8 minutes, 
the gut was again washed out in the vessel that contained besides 
the Tyrode also dialysate; the consequence was that the subsequent 
pilocarpin-action was less again (e); thereupon the gut was washed 
