934 
short time after, caused again a rise of 38 (fig. 3c) as before the 
dialysate injection. But after injecting dialysate again the adrenalin 
yielded a rise of the bioodpressure of 66 mm. Hg. (fig. 3d); after- 
wards it fell again to the original value of 38. 
In 7 experiments we have examined a decapitated cat for the 
effect of the dialysate’) of peptone on the intensifying action of 
adrenalin on the bloodpressure. In 6 of them we obtained a positive 
result, in one only a negative one. 
As stated in our first communication, it had appeared that peptone 
exerts a different influence upon the surviving gut from that of the 
dialysate. 
We deemed it useful, therefore, to examine also the action of the 
residue after dialyzation. 
It is difficult, of course, to make minute quantitave observations 
of such a complicated substance as Witte’s peptone. 
Nevertheless our experiments have clearly demonstrated that the 
intensifying action on the rise of the bloodpressure caused by adrenalin 
is effected in the first place by the dialysate), in a smaller measure 
by the residue and by Witte’s peptone itself. 
In the above experiments we have made use intentionally of 
decapitated and decerebrated animals to avoid narcosis. Our arguments 
for doing so were the following: First it is known that the symptoms 
produced by the anaphylactic shock are very similar to those which 
result from a peptone-injection. Secondly, it is also known that the 
symptoms of the anaphylactic shock decrease when the animal has 
first been nareotized. So we were right in using non-narcotized 
animals since e.g., as observed heretofore, Witte’s peptone exerts a 
distinct effect on the blood-pressure-raising action of adrenalin in 
the decapitated cat, not, however, in the narcotized rabbit. 
After we had discovered that the peptone-dialysate had a marked 
effect on the action of adrenalin in the decapitated cat, it was inter- 
esting to study this action also in the rabbit and more particularly 
in the decerebrated rabbit. It appeared, indeed, in a single case that 
the adrenalin-action is intensified by the dialysate, but this is not 
the rule. It is not easy to account for this phenomenon. We can 
1) The dialysate used was obtained by dialysing 7!/, grms of Witte's peptone 
for three days in running water. The dialysate was ultimately evaporated to 
dryness, and was made up to 300 c.c. As much NaCl was added as would raise 
the percentage to 0,9. Afterwards we discovered that this method did not at all 
afford any dialysate of a constant action. Sometimes we obtained dialysates that 
were completely inactive. For the present we are not able to account for this 
phenomenon. 
