935 
only call attention to the fact that, in the cat, small doses of adrenalin 
mostly produce a fall in the blood-pressure, and that peptone on the 
other hand would seem to hinder this fall. In the rabbit adrenalin 
has not such a lessening effect on the bloodpressure. 
Before proceeding to the discussion of this phenomenon we must 
first state that an intensifying effect on the adrenalin-action has 
been described for other substances already some time ago. Kraus 
and FrirpentHaL') had shown that the effect on the rise of blood 
pressure of adrenalin is intensified by injection of thyreoidin-extract, 
which Storm van Leeuwen has been able to corroborate in his 
personal investigations. °) 
FrönrrcH and Loewr®) had demonstrated that in the cat the adre- 
nalin action can be intensified by previous cocain-injection, while 
Cuiart and Froxiicn *) found that substances that precipitate calcium 
(e.g. oxalic acid), also intensify the adrenalin-action. Krepinow °) found 
an intensified adrenalin-action after injection of hypophysis-extract 
into the rabbit. These findings were corroborated by Nrcurmscu ‘), 
by Atria‘), and by H. Borner ‘). 
H. Borner believes that the influence of hypophysin on the adre- 
nalin-action is not of necessity due to a sensibilization caused by 
hypophysin, but may be ascribed to the circumstance that hypo- 
physin is deleterious to the cardiac action in the rabbit — and the 
rabbit is just the animal with which the phenomenon occurs — by 
which hurtful influence the velocity of the circulation of the blood 
is lessened, so that a quantum of adrenalin, given in a definite space 
of time, is diluted less and can exert a stronger action. In the cat 
hypophysin does not effect the adrenalin rise of the bloodpressure — 
) Kraus and FrimpentHAt. Ueber die Wirkung der Schilddriisenstoffe. Berl. 
Klin. Wochenschr. 1908. NO. 38. 
*) W. Storm van Leeuwen. Physiologische waardebepalingen van geneesmid- 
delen. (Thesis 1919). 
3) A. Froenucu and O. Loews. Ueber eine Steigerung der Adrenalinempfind- 
lichkeit durch Kokain. Arch. f. exp. Path. und Pharm., Bd. 62, p. 59, 1910. 
BR. OCntant and A. Froeaticu. Erregbarkeitsveränderungen des vegetativen 
Nervensystems durch Kalkentziehung. Arch. f.exp. Path.u. Pharm. Bd. 64, p. 214, 1911. 
5) Kertnow. Ueber den Synergismus von Hypophysinextract und Adrenalin. Arch. 
f. exp. Path. und Pharm., Bd. 67, p. 247, 1912. 
®) P. NicuLescu. Ueber die Beziehungen der physiologischen Wirkungen von 
Hypophysenextract, Adrenalin, sowie Mutterkornpräparaten und Imidozalyläthylamin. 
Zeitsch. f. exp. Path. und Ther. Bd. 15 p 1, 1914. 
7) Y. Amita. Zur Kenntnis der Vituitrinwirkung. Skandinavisches Arch, f. Physi- 
ologie Bd. 31 p. 331 1914. 
*) H. Bonsen. Ursache der Steigerung der Adrenalinwirkung auf den Kaninchen- 
blutdruck durch Hypophysenextracte. Arch. f. exp. Path. und Pharm. Bd. 79 p+ 
218. 1915, 
