967 
of both kinds of cells however ceases, and makes place for a slow 
and regular increase. If on the following day the examination is 
made anew, then mostly a slight (at times a considerable) leuco- 
eytosis is observed, with, perhaps, on an average a relative increase 
of the quantity of polynuclear leucocytes (e.g. rabbit IL), but still 
mostly a very large majority of lymphocytes exists. Repeated 
injections always show the same phenomenon: Thus the local distur- 
bance of equilibrium causes a reaction in the blood which lasts for 
a short time which reaction however is soon restored to equilibrium 
again. Also in the case of a many times repeated injection we always 
found this quick return to normal conditions. 
Already in the contemplation of this reaction on the formula of 
the white blood corpuscles in the circulating blood we therefore 
come across difficulties if we adhere to a principial difference between 
lymphocytes and leucocytes; for blood consists mainly of lymphocytes; 
after an injection we see all the elements disappear simultaneously 
from the blood but still the result is an exudation which consists 
almost wholly of polynuclear cells. 
To explain this, several things were possible. 
Firstly: There is the possibility that the lymphocytes, unlike the 
polynuclear cells, do not permeate through the vessels but are only 
retained in the capillaries and afterwards return again to the circu- 
lating blood. [t is not probable that this is exclusively the case 
because different researchers who have studied the formation of 
exudation saw besides the emigration of polynuclear cells also that 
of lymphocytes (ScHwarz *), Maximov’) and others). 
Secondly: It is possible that the emigrated leucocytes remain 
somewhere in the tissues after the emigration. This is in accordance 
with the organisatory tendencies of the lymphoid cell type. 
Thirdly. There is the possibility that all blood cells emigrate but 
that during that process the lympbocytes, to some extent at least, 
get converted into polynuclear cells. The last exposition thus brings 
with it at the same time the acceptance of the unitarian point of 
view. By accepting this possibility of transition it will become clearer 
that during the course of life the number of lymphocytes in the 
blood inspite of the continual influx undergo a percentile decrease, 
instead of still increasing, as would have to be expected, because 
there is hardly any destruction of lympbocytes to be seen, and 
emigration does not take place to the same extent as with the poly- 
nuclear cells. If however we accept that there is a continual tran- 
1) Wien. Klin. Wochenschr., 1904, p, 1173. 
4) Ziea.er’s Beiträge, 38, p. 801, 1905, 
