971 
affinity for the tissues (capillary attraction) and the tissue elements 
in their turn for the blood. We can now further accept with reason 
that the tissue cells, the lymphocytes, as soon as they have entered 
the blood, will not retain their properties which they have in the 
tissues, unchanged; as all living matter under changed circumstances 
they will change their protoplasm, for all cell life is nothing but 
the interchange of protoplasm with the environment. 
Where now the neutrophile cells can only exist in the blood it 
is obvious to reason that the origin of the neutrophile granulation, 
with all vital properties connected with it, must be an issue of the 
conditions of life made possible in the blood, whatever these condi- 
tions may be (eg. can be mentioned the presence of red blood 
corpuscles, higher albumen percentage etc, etc.). The one affects the 
other and vice versa; for instance it could readily be supposed that 
the formation of red blood corpuscles and neutrophyles results from 
the higher albumen percentage, and again that the latter in its turn 
owes ifs origin to the said cell elements. It is just also possible 
that definite changes in the blood (slow current or modified reaction) 
form the stimulus which leads to the transformation of the proto- 
plasm. 
From this follows that by the continual supply of tissue cells to 
the blood a kind of equilibrium ensues. The constantly formed 
neutrophile cells which are the chief bearers of the blood charac- 
teristics will also have the greatest tendency to emigrate; since, 
however, their protoplasm is changed irreversibly they very soon 
perish in the tissues and that for the greater part lyticallvy. This 
emigration will always take place if the contrast between blood and 
tissue becomes greater, and this will, inter alia, be the case in 
every abnormal function of the tissue which is the result of an 
injection. The increased contrast will lead to a more abundant emi- 
gration of polynuclear cells and to strong local attraction of the blood 
lymphocytes. By this accumulation into masses in the capillaries the 
contrast is, however, soon neutralised i.e. the difference between 
blood and tissue becomes less evident; so called myeloid tissue 
comes into being; on the one hand the endothelial cells form new 
capillaries and thereby come into contact with the tissue, on the other 
hand also lymphocytes, granulated cells, and blood albumen enter 
amongst the tissue elements. The embryonic state returns, the diffe- 
rent types of cells found here, keep another in equilibrium and here 
we also notice the change of lymphocytes into granulated cells 
which now can emigrate further to the exudation, if the stimulation 
of the tissue still continues, or enter the blood. In agreement with 
