POISONOUS PROPERTIES OF THE WHORLED MILKWEED. 

 Table 3. — A. pumila — Duration of sickness in cases of recovery. 



Desicnation of 

 animal. 



Duration of symptoms. 



Designation of 

 animal. 



Duration of symptoms. 





lday. 



1 day. 



2 days 2 J hours. 

 2 days 4 hours. 

 74 hours, 

 l'day 1 hour. 



1 day 17 hours. 



2 days 4J hours. 



Sheep 554 



2 days 8 hours. 



Sheep 482 . . 



Sheep 546 



3 days 9?; hours. 



Sheep 4*6 . . 



Sheep 512 



2 days ih hours. 



Sheep 536 



Sheep 520 



1 day. 



Sheep 539 



Sheep 552 



Sheep 539 



Sheep 516 



Sheep 542 



1 day 8 hours. 

 4 days. 





5 days. 



Sheep 547 











It will be noticed that the symptoms continued from a minimum of 

 7-J hours to a maximum of 5 days. With the exception of Sheep 539 

 the dosage was gradually increased in the order of the table. While 

 there was no exact relation between the size of the dose and the dura- 

 tion of the symptoms, in a very general way the greater doses caused 

 the more prolonged symptoms. 



Of the two animals that died, death followed in Sheep 519 in 32 

 hours, and in Sheep 547 in 38 hours. 



AUTOPSIES. 



The findings from the post-mortem examinations of the two cases 

 that terminated in death were not very positive. In each case the 

 animal was bloated and there was some gas in the alimentary canal. 

 However, so far as appeared without microscopic examination, there 

 were no clearly marked lesions in any of the organs. 



MICROSCOPIC CHANGES IN TISSUES OF SHEEP KILLED BY "ASCLEPIAS PUMILA." 



Liver. — The hepatic cells in the two fatal cases were swollen so as to 

 crowd the blood largely out of the capillaries. Cloudy swelling was 

 pronounced in the liver of Sheep 547, the cytoplasm of the hepatic 

 cells being very granular and having a ground-glass appearance, 

 which made it difficult to make out fine details. This condition was 

 not so well advanced in Sheep 519. The blood in many veins con- 

 tained much hemosiderin pigment, areas of granular material, pieces 

 of degenerated hej^atic cells, and sometimes portions of epithelium 

 from the walls of the veins. Some of the veins were engorged, others 

 not. The bile ducts were often catarrhal. The changes in the hepatic 

 cells in both animals, especially in Sheep 547, were more pronounced 

 than in the A. galioides cases. 



Kidneys. — The changes were practically like those found in the 

 A. galioides cases, consisting of areas of congestion and edema and a 

 swollen and somewhat degenerated condition of the epithelium, par- 

 ticularly in the convoluted tubules. In many tubules the lumina were 

 practically filled by the swollen cells. Other cells were degenerated 

 and partly disintegrated. Most nuclei stained well; a few stained 



