8 BULLETIN 942, U. S. DEPARTMENT OF AGRICULTURE. 



very faintly, while others were wrinkled. In the congested areas there 

 were deposits of hemosiderin pigment, much of it being in tubule 

 epithelial cells. Apparently pronounced hemolysis occurred. 



Heart. — This tissue was mildly congested in some areas in Sheep 

 547, and a few minute hemorrhages occurred. In both animals the 

 cross-striated appearance was less pronounced than usual, especially 

 in areas where the cytoplasm was more granular than normal. This 

 was less marked than that found in some of the A. galioides cases, but 

 was not materially different and probably was the result of excessive 

 activity of the cardiac muscle. 



Lungs. — The sections of the lungs of Sheep 547 showed congestion ; 

 those of Sheep 519 did not. In both cases, however, hemosiderin 

 pigment was present and thrombi were found in the arteries. While 

 these thrombi differed somewhat in detail their origin may have been 

 and probably was the same. The fact that they were found in arteries 

 indicates that they were embolic in nature and possibly originated in 

 the liver. 



Thyroid. — The thyroid from each animal appeared to be normal 

 except for a possible slight increase in connective tissue in Sheep 540, 

 which had no connection with the A. pumila poisoning. In the A. 

 galioides cases the thyroid tissue was congested. 



Thymus. — The thymus from Sheep 547 was the only one examined. 

 It was severely congested and was hemorrhagic as well as edematous. 

 The medullary portion of the lobules was especially full of blood. 

 No changes of importance were noted in the lymphoid cells, though 

 in places large cells with finely granular cytoplasm, apparently 

 phagocytic in nature, were present. 



Nervous system. — The pronounced congestion noted in various 

 parts of the nervous system in the A. galioides cases was absent in 

 both the sheep poisoned by A. pumila, though all portions examined 

 were somewhat edematous. In the lumbar cord of each case, and in 

 the cerebrum and the cerebellum of Sheep 519, a small amount of 

 diapedesis of erythrocytes had occurred. The nerve cells of the 

 medulla and spinal cord and the Purkinje cells of the cerebellum in 

 both cases had undergone marked changes. The Purkinje cells of 

 sheep poisoned with A. galioides were found to show marked, or in 

 some cases, extreme fatigue effects. Changes in other nerve cells 

 were apparently fatigue effects. 



Thrombi were found in the meninges and sometimes in the nervous 

 tissue. Some of these contained fibrin, others appeared hyalin. 



Alimentary canal. — The only portion showing changes which may 

 be considered due to the A. pumila was in the ileum and suggested 

 the presence of an irritant. The ileum of Sheep 547 was mildly con- 

 gested, and hemorrhages had occurred. In the mucosa was an ab- 

 normal number of mononuclear leucocytes. A similar invasion, but 



