38 BULLETIN 125, U. S. DEPARTMENT OF AGRICULTURE. 



there was no evidence of any good result. All these experiments had 

 been with single doses. In 1914 two animals were treated, one 

 with two doses of 10 grains each of caffein sodiobenzoate adminis- 

 tered subcutaneously, and one with three doses of 5 grains each. 

 One of these animals died and one recovered, but in neither case 

 could it be seen that the remedy was advantageous. It seemed to 

 be clear that while caffein might be considered a logical remedy it 

 failed in practical application. 



STRYCHNIN. 



Although the work of Hunt quite clearly indicated that strychnin 

 was not beneficial, it seemed best to try a few experiments to see 

 whether, by its stimulating effect, it might not aid in relieving the 

 depression of the animals. Six cases were treated by subcutaneous 

 injections. In two of these cases eserin was also used, and in one 

 case gin. There was an apparently beneficial effect in one case, but 

 a study of all fails to show any good results which could be fairly 

 considered as due to strychnin. 



ESERIN, EPSOM SALTS, LINSEED OIL. 



With the idea that relief might be brought about by an increase in 

 intestinal elimination, eserin was administered subcutaneously, and 

 Epsom salts and linseed oil per os; no reduction of toxic symptoms 

 could be seen. 



CHARCOAL. 



Dr. Sollman suggested to the writers that charcoal, by adsorption, 

 might be beneficial. Three experiments were made with this, in 

 one case combined with linseed oil. No beneficial results followed. 



WHISKY AND DIGITALIS. 



In some cases of extreme depression whisky seemed to have an 

 effect in bridging over a period when death might otherwise have 

 followed. The same thing is true of digitalis, which in one or two 

 cases may have saved the life of the patient. Neither drug, however, 

 had any marked effect. It can only be said that if the symptoms of 

 the animal are carefully watched, times will be found when whisky 

 or digitalis may be administered advantageously. Inasmuch as the 

 life of the individual sheep is of small importance, these remedies are 

 of little practical use. 



POTASSIUM PERMANGANATE. 



Especial Interest attaches to the experiments with potassium 

 permanganate, since it is the remedy that has been most commonly 

 recommended for plant poisoning. The dosage advised for a mature 

 sheep has been 5 to 9 grains. This was used at first in the experi- 

 mental work, and when no beneficial results appeared it was increased 



