2 VASSAL. 



syphilis (Uhlenhuth, Hoffmann, Eoscher, Metchnikoff, Hallopea, Lassar, 

 etc.) ; iu general paralysis (Marie) ; in the spirillosis of fowls (Ulilen- 

 huth, Gross and Bickel) ; in pellagra (Bahes and Vasiliu). On the 

 other hand atoxyl has been inefficacious in tick fever (Breinl, Kinghorn 

 and Vassal). 



Arsenical preparations have been specified for some time as effective 

 against malaria (Boudin, Hosier and Guerin), but the use of atox}'! for 

 such a purpose does not appear to have given rise to many researches in 

 this direction until the present time. R. Koch in Africa, has had the 

 opportunity of studying its effects on the negroes attacked with sleeping 

 sickness and malaria at the same time. The antiparasitic power of 

 atoxyl was supposed to limit the action of the Trypanosoma Gambiense 

 and only slightly to influence the evolution of Laveran's haematozoou. 



THERAPEUTIC DOSES OF ATOXYL. 



The experimental therapeutic tests have shown us the different qualities 

 of atoxyl and the proper doses to be employed. 



F. Mesnil, Nicolle. and Aubert for instance give 2.5 centi<>:rams for every 1,000 

 grams of the animal's weight. Metchnikoff prevents the primary eruption of 

 the syphilitic chancre in the monkey, by giving it 33 milligrams for every kilogram 

 of the animal's weight. According to this investigator the prophylactic dose for 

 a man of CO kilograms of weight should be at the most 2 grams. Hallopeau keeps 

 within these limits in his preventive treatment, but inoculates from 5 to 7.5 grams 

 during a period of three weeks as a precautionary measure in syphilis. For sleeping 

 sickness in the negro, E,. Koch injects 0.50 gram of the drug every other day 

 during two months. 



Our patients here were composed exclusively of xinnamese weighing 

 on an average 35 to 40 kilograms. We used noncrystallized atoxyl 

 "Martini Renfelde" from Berlin. The strength of the solution was 10 

 per cent ; the injections were made as with quinine, deep into the muscles 

 of the buttocks, except in one case (observation 7) where they were made 

 under the skin of the abdomen. The solutions were always freshly 

 prepared and boiled in a water bath for ten minutes before use. The 

 maximum dose of atoxyl employed at one inoculation was 1 gram. The 

 same solution (10 percent) was employed per os in the dose of 10 

 centigrams of atoxyl a day during ten days or for a longer period with- 

 out interruption. 



We administered the atoxyl in two different ways : 



1. Alone in hypodermic injections. 



2. Associated with hypodermic injections of hydrochlorate of quinine given either 

 by injections or per os. 



The resiilts obtained are the subject of the present memoir. We will 

 divide them into two parts: (I) Treatment by atoxyl alone; (II) treat- 

 ment by atoxyl with quinine. 



