ATOXYL IN THE TREATMENT OF MALARIA. 7 



Malarial jDatients given the mixed treatment tend to increase in 

 weight to a remarkable degree. 



The red cells nndergo no modification and do not increase in number. 

 The percentage of the different leucocytes remains the same; however, 

 the size of the large mononuclear leucocytes seemed increased after the 

 employment of atoxyl. 



CONCLUSIONS. 



1. Used alone, atoxyl does not exercise a specific action in malaria. 



2. Associated with quinine, it is capable of bringing about a rapid 

 improvement in health and of hastening convalescence. 



3. In cachexia and chronic forms of malaria, quinine with atoxyl ap- 

 pears to be more officacious than quinine alone. 



4. Atoxyl in large doses is sometimes borne with difficulty and may 

 even give rise to accidents. 



REPEKENCES. 



Babes, V., and Vasiliu, A., Berl. klin. Wchnsch. (1907), 44, 879; 1189. 



Breinl, A., and Kinghorn, A., Mem. Liverpool School Trop. Med. (1905), 21, 1. 



Egiierin, Ann. med. colon. (1902). 



Hallopeau, Bull. Acad. med. (1907), III, 57, 702; 722. 



Koch, R., Deutsche med. Wchnsch. (1907), 33, 49;. 1889. 



Lassar, 0., Berl. klin. Wchnsch. (1907), 44, 684. 



Laveran, Bull. Acad. med. (1907), III, 57, 325. 



M&Tie, Soc. Therap. (1907). 



Mesnil, F., Nicolle, M., & Aubert, P., Ann. Inst. Pasteur (1907), 21, I. 



Mesnil, F., & Nicolle, M., Ibid. (1906), 20, 417. 



Metehnikoff, Hid. (1907), 21, 753. 



Moore, B., Nierenstein, M., Todd, J., Bio-Chem. Journ. (1907), 2, 300. 



Mosler, Deutsches Arch. f. klin. Med. (1875), 15, 53. 



Salmon, P., Compt. rend. Soc. biol. (1907), 62. 



Thomas, H. W., Brit. Med. Journ. (1905), 1, 1140; Proc. Roy. 8oc. London (1905), 



s. B, 76, 590. 

 Uhlenhuth, P., Hoffmann, E., Roscher, K., Deutsche med. Wch)}sch. ( 1907), 33, 873. 

 Uhlenhuth, P., Gross, & Bickel, Ibid. ( 1907), 33, 129. 

 Vassal, J. J., Compt. rend. Soc. biol. (1907), 62. 

 Waelseh, Miinchener med. Wchnsch. (1907), 54, 937. 



