IMMUNIZING CATTLE. 



355 



Bullock No. 18 was inoculated with 0.5 cubic centimeter of virulent 

 blood and 75 cubic centimeters of anticattle-plague sevum on the 28th day 

 of June and was found dead on the morning of July lOth. (Chart 

 No. 18.) 



Bullock No. 19 inoculated with 0.5 cubic centimeter of virulent blood 

 and 100 cubic centimeters of anticattle-plague serum died twelve days 

 after inoculation. (Chart No. 19.) 



Bullock No. 20 died within fourteen days after having received 0.5 

 cubic centimeter of vinilent blood and 125 cubic centimeters of anticattle- 

 plague serum under the skin. (Chart No. 20.) 



Bullock No. 22 received 0.5 cubic centimeter of virulent blood and 

 50 cubic centimeters of anticattle-plague serum. He developed typical 

 cattle plague from which he recovered. (Chart No. 22.) 



Bullock No. 23, after inoculation with 0.5 cubic centimeter of virulent 

 blood and 75 cubic centimeters of anticattle-plague serum, had a mild 

 attack of cattle plague from which a good recovery was made. (Chart 

 No. 23.) 



Bullock No. 24 received an inoculation of 0.5 cubic centimeter of 

 virulent blood and 100 cubic centimeters of anticattle-plague serum. 

 A very mild attack of cattle plague followed from which an uneventful 

 recovery resulted. (Chart No. 24.) 



Bullock No. 25, having received 0.5 cubic centimeter of anticattle- 

 plague serum, showed a slight rise of temperatui'e and made a rapid 

 recovery. (Chart No. 25.) 



The results are summarized in the following table. 



Number 

 of bul- 

 locks. 



1 

 Virulent 

 blood. 



16 



0.5 



17 



0..5 



18 



0.5 



19 



0.5 



20 



0.5 



22 



0.5 



23 



0.5 



24 



0.5 



25 



0.5 



Serum. 



None. 

 50 

 75 

 100 

 125 

 50 

 75 

 100 

 125 



Result. 



Remarks. 



Died Control. 



Died j Not trentL'd previously. 



Died ; Not treated previously. 



Died I Not treated previously. 



Died — 

 Lived. 

 Lived- 

 Lived- 

 Lived- 



Not treated previously. 

 Treated previously. 

 Treated previously. 

 Treated previou.'ily. 

 Treated previou.sly. 



CONCLUSION. 



Ap])arently anticattle-])lague serum, when repeatedly injected under the 

 skin of healthy, non-immune bullocks, does not lead to the ])roduction of 

 antiimmune bodies. 



The more serum injected into an animal the milder is the attack of 

 cattle plague which follows inoculation with virulent blood. 



Tn this respect the immunity reactions in cattle i)lague aic similar to 

 those observed in manv infections of known l)acterial oi-ii)in. 



