384 RUEDIGEIJ. 



TREATMENT. 



Little or nothing can be accomplished with drugs. The administra- 

 tion of specific immune serum gives good results where treatment is 

 begun early enough. The seram is prepared by hyper-immunizing cattle 

 against the disease. This is accomplished as follows : Blood of an animal 

 sick with cattle plague transmits the disease when injected under the 

 skin of a non-immune animal. If compelled to start without a curative 

 serum, an animal which has spontaneously recovered from the disease is 

 given an injection of 100 cubic centimeters of virulent blood (blood of 

 an animal suffering from an acute form of the disease) under the skin. 

 Within a few days the animal usually sickens, with a slight rise of 

 temperature from which it soon recovers. Having recovered from the 

 effects of the inoculation, the animal receives a larger quantity of virulent 

 blood, and these treatments are repeated until at least 1,000 cubic centi- 

 meters have been given at one dose. The process of immunization should 

 not require more than three months' time, and an animal so treated 

 usually furnishes a good protective serum. Once in possession of im- 

 mune serum, any animal may be immunized by injecting serum and 

 virulent blood simultaneously. Usually from about 50 to 100 cubic 

 centimeters of specific serum are injected under the skin on one side of 

 the animal and from 0.5 cubic centimeter to 1 cubic centimeter of 

 virulent blood under the skin on the other side of the animal. Within 

 a week the animal sickens and goes through a mild attack of cattle plague. 

 Should the temperature rise very high, 41° C. or over, serum treatment 

 should be resorted to. After recovery from an attack of the disease, there 

 is practically no danger of killing the animal by injecting virulent blood. 

 A dose of 500 cubic centimeters may be given vnthout hesitation. The 

 following may be considered a safe procedure in immunizing an animal 

 for curative serum. From about 50 to 100 cubic centimeters (accord- 

 ing to the size of the animal and the potency of the seram) of immune 

 serum and from 0.5 cubic centimeter to 1 cubic centimeter of virulent 

 blood are injected simultaneously. I do not fix a rule regarding the 

 exact quantity of immune seram an animal undergoing immunization 

 should receive. Here in the Philippine Islands we have to deal with 

 cattle from China, from India, and from Australia, and with both cattle 

 and carabaos from various parts of the Philippine Islands, some of which 

 are highly susceptible, others but moderately so, others show a consider- 

 able, degree of insusceptibility, while still others are entirely immune. To 

 be conservative and economical is the best advice I can give. 



After the animals have recovered from the first reaction, the following 

 quantities of viralent blood may subsequently be injected : 250, 500, 750 

 and 1,000 cubic centimeters. Larger doses of virulent blood such as 

 500, 1,000, 2,000 and 4,000 cubic centimeters may also be given. From 

 seven to ten days after recovery from the effects of the last inoculation 



