THE PHILIPPINE 



Journal of Science 



B. Medical Sciences 



Vol. IV DECEMBBE, 1909 ' Xo. 6 



THE SPECIFIC TREATMENT OF CARCINOMA.^ 



(Preliminary Report.) 



By Arthur F. Coca and Philip K. Gilman. 



{From the Biological Laboratory, Bureau of Science, Manila, P. I., and the 

 Surgical Clinic, Philippine Medical School.) 



Since the first experiments by Jensen made in 1903, in immunizing 

 against malignant growths, man}' investigations liave been undertaken 

 on the same subject, in all of which the object of study has been a 

 tumor of some lower animal. 



Immunity of greater or less degree has been produced in the mouse, 

 the rat, the dog and the rabbit against many different kinds of tumor; 

 in some instances, howevei', the attempts to immunize have failed, or 

 have even resulted in an increased rapidity of growth. 



It has been found that while the most marked degree of resistance 

 to the development of transplanted tumor cells is called forth by previous 

 inoculation with the protoplasmic substances of the particular tumor 

 under investigation, -a good measure of resistance can be produced by 

 the injection of normal tissues, adult or embryonal, provided they be of 

 the same class as the tumor, i. e., epithelial or connective tissue as the 

 case may be. Studies by Ehrlich seemed to show that the induced 

 immunity to tumors in lower animals is not absolutely blasto-specific ; 

 but this view has been controverted by Bashfoi'd who showed that only 

 the epithelial covering of the embryo, not the rest of the body, could 

 be successfully used in immunizing against epithelial tumors. 



' To be read before the annual meeting of the Manila ^Medical Society, January 

 3, 1910. 



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