SPECIFIC TREATMENT OF CARCINOMA. 401 



. Our thanks are due Dr. John E. McDill, Professor of Surgery, Philip- 

 pine Medical School, who has placed at our disposal all cases of malignant 

 disease admitted to his clinic since we began this work. 



SUMMARY AND CONCLUSION. 



1. The protoplasmic substances of malignant epithelial tumors in 

 human beings can be injected subcutaneously in large quantities without 

 injurious results. 



2. In three cases affected with carcinoma, such injections have been 

 followed by the softening and disappearance of tumor masses measuring 

 in diameter from 2 to 4 centimeters. 



In a fourth case, a rapidly growing lump appeared near the site of 

 the excised cancer two days after treatment. Several days later, when 

 the lump had reached a diameter of 4 centimeters, the growth ceased 

 and subsequent microscopic examination showed it to be a firmly en- 

 capsulated mass of djdng epithelial-like cells. 



Three other surgically absolutely inoperable cases, in two of which 

 visible amounts of cancer tissue were left unexcised, have remained until 

 now, i. e., for from five weeks to six months, free from recurrence of 

 the disease. 



Seven other cases have remained free from a return of the disease 

 for from one to seven months. Two of these were designated as ^'curable 

 by operation ;" three were designated as "probably curable by operation ;" 

 and two were designated as "of doubtful curability by operation." 



In only one case has the disease returned after treatment. In this 

 case the material used for vaccination was rendered inert by too vigorous 

 disinfection. 



Hitherto no case of sarcoma has^come to treatment; however, in 

 view of the failure of the procedure to affect the course of Hodgkin's 

 disease, the outlook for sarcoma is not promising. 



3. Tumor cachexia is not increased by the rapid absorption of large 

 quantities of tumor tissue; on the contrary, large injections- of tumor 

 material seem to cause the disappearance of the cachexia. 



While tliis paper was in press further experiments seem to indicate; 



( 1 ) That the efficacy of the treatment is indirectly proportional to the amount 

 of malignant tissue left in the body, and, within certain limits, directly propor- 

 tional to the amount of tumor-cell substances injected and to the number of such 

 injections made. 



(2) That a carcinoma in one individual can be successfully treated with 

 injections of material from a carcinoma of the same kind taken from another 

 individual. 



(3) That one-half per cent of carbolic acid does not destroy the "vaccine" 

 within thirty-six hours if the latter is kept at a temperature of 7° centigrade. 



