458 WHITMORE. 



The tuberculins used in these experiments had been in stock in the 

 hiboratory for a long time and the human tuberculin yielded only a 

 slight skin reaction, while the bovine gave a well-marked one. Since 

 both tuberculins yielded equally strong fixation of complement with the 

 tuberculous sera, we believe that the experiments indicate that the sub- 

 stances in the tul;erculins which are concerned with the fixation of 

 complement i-eaction are not identical with those calling forth the 

 cutaneous reaction. 



It is seen from the table that the two tuberculins yielded approxi- 

 mately the same degree of fixation of complement with the various tuber- 

 culous sera and therefore the method is not an aid in differentiating 

 the two types of infections. This can only be done by the isolation of 

 the infecting organism in pure culture followed by a careful study of 

 its cultural characteristics and pathogenicity for animals. 



The cases treated were divided into five series of 20 cases each. They 

 were, as nearly as possible, so assigned that the men of one series were in 

 approximately the same physical condition and the same stage of the 

 disease as were the men in any other series. 



The first of the five series was further divided into two groups 

 (A and B), receiving tuberculins by mouth and hypodermically, respec- 

 tively. 



The second series of twenty men was given succinimide of mercury 

 according to the method of Wright ^ of the United States Navy. 



The third series was given atoxyl or the similar compounds, soamin 

 and arsacetin, intramuscularly. 



The fourth series was given cinnamate of mercury intramuscularly. 

 The cinnamate of mercury was made at my request by Doctor Bacon of 

 the chemical laboratory of this Bureau. I hoped in this single drug to 

 combine whatever of value there might be in both the Landerer and 

 Wright methods of treatment. Landerer's idea was that the cinnamic 

 acid caused a leucocytosis and set up an aseptic inflammation about the 

 tuberculous focus resulting in cicatrization of the latter. He used chiefly 

 sodium cinnamate (hetol) and preferred intravenous injection, although 

 he used intramuscular injections almost exclusively for children. He 

 considered that the intramuscular injections were of far less value than 

 the intravenous, and that they were useless in severe cases. Lan- 

 derer used small doses — 35 milligrams, or rarely 50 milligrams as the 

 maximum dose — while certain French writers have reported good results 

 from using much larger doses. 



Series 1, 2, 3, and 4 received no other medicinal treatment except an 

 occasional cathartic or sedative cough mixture. 



'New York Med. Jour. (1908), 88, 385, and U. S. Naval Med. Bull. Wash. 

 (1908), 2, ]. 



